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10.1080/07391102.2020.1761882 http://scihub22266oqcxt.onion/10.1080/07391102.2020.1761882 32338164!7222627!32338164     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biomol+Struct+Dyn 2021 ; 39 (9): 3204-3212 Nephropedia Template TP {{tp|p=32338164|t=2021. SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective |pdf=|usr=}}{{32338164}} gab.com Text SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective JO: J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=32338164 #FOAvip New treatment against SARS-CoV-2 now is a must. Nowadays, the world encounters a huge health crisis by the COVID-19 viral infection. Nucleotide inhibitors gave a lot of promising results in terms of its efficacy against different viral infections. In this work, molecular modeling, docking, and dynamics simulations are used to build a model for the viral protein RNA-dependent RNA polymerase (RdRp) and test its binding affinity to some clinically approved drugs and drug candidates. Molecular dynamics is used to equilibrate the system upon binding calculations to ensure the successful reproduction of previous results, to include the dynamics of the RdRp, and to understand how it affects the binding. The results show the effectiveness of Sofosbuvir, Ribavirin, Galidesivir, Remdesivir, Favipiravir, Cefuroxime, Tenofovir, and Hydroxychloroquine, in binding to SARS-CoV-2 RdRp. Additionally, Setrobuvir, YAK, and IDX-184, show better results, while four novel IDX-184 derivatives show promising results in attaching to the SARS-CoV-2 RdRp. There is an urgent need to specify drugs that can selectively bind and subsequently inhibit SARS-CoV-2 proteins. The availability of a punch of FDA-approved anti-viral drugs can help us in this mission, aiming to reduce the danger of COVID-19. The compounds 2 and 3 may tightly bind to the SARS-CoV-2 RdRp and so may be successful in the treatment of COVID-19. Twit Text FOAVip SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective ????J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=32338164 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32338164 #FOAvip English Wikipedia <ref>{{Cite pmid|32338164}}</ref> SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective #MMPMID32338164 Elfiky AA J Biomol Struct Dyn 2021[Jun]; 39 (9): 3204-3212 PMID32338164show ga New treatment against SARS-CoV-2 now is a must. Nowadays, the world encounters a huge health crisis by the COVID-19 viral infection. Nucleotide inhibitors gave a lot of promising results in terms of its efficacy against different viral infections. In this work, molecular modeling, docking, and dynamics simulations are used to build a model for the viral protein RNA-dependent RNA polymerase (RdRp) and test its binding affinity to some clinically approved drugs and drug candidates. Molecular dynamics is used to equilibrate the system upon binding calculations to ensure the successful reproduction of previous results, to include the dynamics of the RdRp, and to understand how it affects the binding. The results show the effectiveness of Sofosbuvir, Ribavirin, Galidesivir, Remdesivir, Favipiravir, Cefuroxime, Tenofovir, and Hydroxychloroquine, in binding to SARS-CoV-2 RdRp. Additionally, Setrobuvir, YAK, and IDX-184, show better results, while four novel IDX-184 derivatives show promising results in attaching to the SARS-CoV-2 RdRp. There is an urgent need to specify drugs that can selectively bind and subsequently inhibit SARS-CoV-2 proteins. The availability of a punch of FDA-approved anti-viral drugs can help us in this mission, aiming to reduce the danger of COVID-19. The compounds 2 and 3 may tightly bind to the SARS-CoV-2 RdRp and so may be successful in the treatment of COVID-19. |*COVID-19[MESH] |*RNA-Dependent RNA Polymerase[MESH] |Antiviral Agents/pharmacology[MESH] |Humans[MESH] |Molecular Dynamics Simulation[MESH] |RNA, Viral[MESH]SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico(epmc).pdf DeepDyve Pubget Overpricing