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10.15252/embr.201949942 http://scihub22266oqcxt.onion/10.15252/embr.201949942 32337838!7271651!32337838     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2020 ; 21 (6): e49942 Nephropedia Template TP {{tp|p=32337838|t=2020. SMaRT lncRNA controls translation of a G-quadruplex-containing mRNA antagonizing the DHX36 helicase |pdf=|usr=}}{{32337838}} gab.com Text SMaRT lncRNA controls translation of a G-quadruplex-containing mRNA antagonizing the DHX36 helicase JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=32337838 #FOAvip Guanine-quadruplexes (G4) included in RNA molecules exert several functions in controlling gene expression at post-transcriptional level; however, the molecular mechanisms of G4-mediated regulation are still poorly understood. Here, we describe a regulatory circuitry operating in the early phases of murine muscle differentiation in which a long non-coding RNA (SMaRT) base pairs with a G4-containing mRNA (Mlx-gamma) and represses its translation by counteracting the activity of the DHX36 RNA helicase. The time-restricted, specific effect of lnc-SMaRT on the translation of Mlx-gamma isoform modulates the general subcellular localization of total MLX proteins, impacting on their transcriptional output and promoting proper myogenesis and mature myotube formation. Therefore, the circuitry made of lnc-SMaRT, Mlx-gamma, and DHX36 not only plays an important role in the control of myogenesis but also unravels a molecular mechanism where G4 structures and G4 unwinding activities are regulated in living cells. Twit Text FOAVip SMaRT lncRNA controls translation of a G-quadruplex-containing mRNA antagonizing the DHX36 helicase ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=32337838 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32337838 #FOAvip English Wikipedia <ref>{{Cite pmid|32337838}}</ref> SMaRT lncRNA controls translation of a G-quadruplex-containing mRNA antagonizing the DHX36 helicase #MMPMID32337838 Martone J; Mariani D; Santini T; Setti A; Shamloo S; Colantoni A; Capparelli F; Paiardini A; Dimartino D; Morlando M; Bozzoni I EMBO Rep 2020[Jun]; 21 (6): e49942 PMID32337838show ga Guanine-quadruplexes (G4) included in RNA molecules exert several functions in controlling gene expression at post-transcriptional level; however, the molecular mechanisms of G4-mediated regulation are still poorly understood. Here, we describe a regulatory circuitry operating in the early phases of murine muscle differentiation in which a long non-coding RNA (SMaRT) base pairs with a G4-containing mRNA (Mlx-gamma) and represses its translation by counteracting the activity of the DHX36 RNA helicase. The time-restricted, specific effect of lnc-SMaRT on the translation of Mlx-gamma isoform modulates the general subcellular localization of total MLX proteins, impacting on their transcriptional output and promoting proper myogenesis and mature myotube formation. Therefore, the circuitry made of lnc-SMaRT, Mlx-gamma, and DHX36 not only plays an important role in the control of myogenesis but also unravels a molecular mechanism where G4 structures and G4 unwinding activities are regulated in living cells. |*G-Quadruplexes[MESH] |*RNA, Long Noncoding/genetics[MESH] |Animals[MESH] |DEAD-box RNA Helicases/genetics/metabolism[MESH] |DNA Helicases[MESH] |Mice[MESH]SMaRT lncRNA controls translation of a G-quadruplex-containing mRNA an(epmc).pdf DeepDyve Pubget Overpricing