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10.1155/2020/6456805 http://scihub22266oqcxt.onion/10.1155/2020/6456805 32337263!7166271!32337263     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2020 ; 2020 (ä): 6456805 Nephropedia Template TP {{tp|p=32337263|t=2020. Effect of Carvacrol, TRP Channels Modulator, on Cardiac Electrical Activity |pdf=|usr=}}{{32337263}} gab.com Text Effect of Carvacrol, TRP Channels Modulator, on Cardiac Electrical Activity JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=32337263 #FOAvip Despite the wide application of carvacrol (CAR) in medicines, dietary supplements, and foods, there is still insufficient electrophysiological data on the mechanisms of action of CAR, particularly with regard to heart function. Therefore, in this study, we attempted to elucidate whether CAR, whose inhibitory effect on both cardiac and vascular TRPM7 and L-type Ca(2+) currents has been demonstrated previously, could modify cardiac electrical activity. We used a combination of optical mapping and microelectrode techniques to track the action potentials (APs) and the spread of electrical activity in a Langendorff-perfused rabbit heart model during atrial/endo/epicardial pacing. Simultaneously, ECG recordings were acquired. Because human trials on CAR are still lacking, we tested the action of CAR on human ventricular preparations obtained from explanted hearts. Activation time (AT), AP duration (APD), and conduction velocity maps were constructed. We demonstrated that at a low concentration (10 muM) of CAR, only marginal changes in the AP parameters were observed. At higher concentrations (>/=100 muM), a decrease in AP upstroke velocity (dV/dt (max)), suggesting inhibition of Na(+) current, and APD (at 50 and 90% repolarization) was detected; also slowing in the spread of electrical signals via the atrioventricular node was observed, suggesting impaired functioning of Ca(2+) channels. In addition, a decrease in the T-wave amplitude was seen on the ECG, suggesting an impaired repolarization process. Nevertheless, those changes occurred without a significant impact on the resting membrane potential and were reversible. We suggest that CAR might play a role in modulating cardiac electrical activity at high concentrations. Twit Text FOAVip Effect of Carvacrol, TRP Channels Modulator, on Cardiac Electrical Activity ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=32337263 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32337263 #FOAvip English Wikipedia <ref>{{Cite pmid|32337263}}</ref> Effect of Carvacrol, TRP Channels Modulator, on Cardiac Electrical Activity #MMPMID32337263 Almanaityte M; Jurevicius J; Macianskiene R Biomed Res Int 2020[]; 2020 (ä): 6456805 PMID32337263show ga Despite the wide application of carvacrol (CAR) in medicines, dietary supplements, and foods, there is still insufficient electrophysiological data on the mechanisms of action of CAR, particularly with regard to heart function. Therefore, in this study, we attempted to elucidate whether CAR, whose inhibitory effect on both cardiac and vascular TRPM7 and L-type Ca(2+) currents has been demonstrated previously, could modify cardiac electrical activity. We used a combination of optical mapping and microelectrode techniques to track the action potentials (APs) and the spread of electrical activity in a Langendorff-perfused rabbit heart model during atrial/endo/epicardial pacing. Simultaneously, ECG recordings were acquired. Because human trials on CAR are still lacking, we tested the action of CAR on human ventricular preparations obtained from explanted hearts. Activation time (AT), AP duration (APD), and conduction velocity maps were constructed. We demonstrated that at a low concentration (10 muM) of CAR, only marginal changes in the AP parameters were observed. At higher concentrations (>/=100 muM), a decrease in AP upstroke velocity (dV/dt (max)), suggesting inhibition of Na(+) current, and APD (at 50 and 90% repolarization) was detected; also slowing in the spread of electrical signals via the atrioventricular node was observed, suggesting impaired functioning of Ca(2+) channels. In addition, a decrease in the T-wave amplitude was seen on the ECG, suggesting an impaired repolarization process. Nevertheless, those changes occurred without a significant impact on the resting membrane potential and were reversible. We suggest that CAR might play a role in modulating cardiac electrical activity at high concentrations. |Action Potentials/drug effects[MESH] |Animals[MESH] |Arrhythmias, Cardiac/drug therapy/metabolism[MESH] |Calcium/metabolism[MESH] |Cymenes/*pharmacology[MESH] |Female[MESH] |Heart Atria/drug effects/metabolism[MESH] |Heart Ventricles/*drug effects/metabolism[MESH] |Humans[MESH] |Male[MESH] |Microelectrodes[MESH] |Middle Aged[MESH] |Patch-Clamp Techniques/methods[MESH] |Rabbits[MESH] |Sodium/metabolism[MESH]Effect of Carvacrol, TRP Channels Modulator, on Cardiac Electrical Act(epmc).pdf DeepDyve Pubget Overpricing