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10.1007/s11239-020-02121-8 http://scihub22266oqcxt.onion/10.1007/s11239-020-02121-8 32335777!7183388!32335777     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Thromb+Thrombolysis 2020 ; 50 (2): 468-472 Nephropedia Template TP {{tp|p=32335777|t=2020. Effects of colchicine on platelet aggregation in patients on dual antiplatelet therapy with aspirin and clopidogrel |pdf=|usr=}}{{32335777}} gab.com Text Effects of colchicine on platelet aggregation in patients on dual antiplatelet therapy with aspirin and clopidogrel JO: J Thromb Thrombolysis http://www.kidney.de/pget.php?&tw=1&pmid=32335777 #FOAvip Platelets aggregation leading to thrombosis plays a pivotal role in the pathophysiology of acute coronary syndrome (ACS) and of stent thrombosis. Antiplatelet therapy with aspirin plus an ADP-receptor inhibitor (ticagrerol, prasugrel or clopidogrel) is recommended to reduce the risk of other platelet-mediated events. Clopidogrel is recommended in patients with Chronic Coronary Syndromes (CCS) or in ACS patients at high bleeding risk. Unfortunately, up to 30% of patients are non-responders to clopidogrel and show residual high platelet reactivity (HPR). Colchicine (COLC) is a drug with cardiovascular effects. We have demonstrated that COLC might exert protective cardiovascular effects by interfering with cytoskeleton rearrangement, a phenomenon involved in platelet aggregation. Here, we investigate in vitro the effects of colchicine on platelet aggregation of patients on DAPT with clopidogrel. Platelets obtained from 35 CCS patients on therapy with clopidogrel were pre-incubated with COLC 10 microM before being stimulated with ADP (20 microM), or TRAP (25 microM) at 0, 30, 60 and 90 min to measure max aggregation by LTA. Platelets not COLC-preincubated served as controls. Seven patients were pre-selected as clopidogrel non-responders. COLC significantly reduced TRAP-induced platelet aggregation in clopidogrel responders and non-responders. Interestingly, COLC inhibited ADP-induced platelet aggregation in clopidogrel non-responders in which ADP still caused activation despite DAPT. We demonstrate that COLC inhibits platelet aggregation in clopidogrel non-responders with HPR despite DAPT with this ADP receptor-inhibitor. Further in vivo studies should be designed to evaluate the opportunity to prescribe colchicine after ACS/CCS to overcome the clopidogrel limitations in the DAPT therapy. Twit Text FOAVip Effects of colchicine on platelet aggregation in patients on dual antiplatelet therapy with aspirin and clopidogrel ????J Thromb Thrombolysis http://www.kidney.de/pget.php?&tw=1&pmid=32335777 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32335777 #FOAvip English Wikipedia <ref>{{Cite pmid|32335777}}</ref> Effects of colchicine on platelet aggregation in patients on dual antiplatelet therapy with aspirin and clopidogrel #MMPMID32335777 Cirillo P; Taglialatela V; Pellegrino G; Morello A; Conte S; Di Serafino L; Cimmino G J Thromb Thrombolysis 2020[Aug]; 50 (2): 468-472 PMID32335777show ga Platelets aggregation leading to thrombosis plays a pivotal role in the pathophysiology of acute coronary syndrome (ACS) and of stent thrombosis. Antiplatelet therapy with aspirin plus an ADP-receptor inhibitor (ticagrerol, prasugrel or clopidogrel) is recommended to reduce the risk of other platelet-mediated events. Clopidogrel is recommended in patients with Chronic Coronary Syndromes (CCS) or in ACS patients at high bleeding risk. Unfortunately, up to 30% of patients are non-responders to clopidogrel and show residual high platelet reactivity (HPR). Colchicine (COLC) is a drug with cardiovascular effects. We have demonstrated that COLC might exert protective cardiovascular effects by interfering with cytoskeleton rearrangement, a phenomenon involved in platelet aggregation. Here, we investigate in vitro the effects of colchicine on platelet aggregation of patients on DAPT with clopidogrel. Platelets obtained from 35 CCS patients on therapy with clopidogrel were pre-incubated with COLC 10 microM before being stimulated with ADP (20 microM), or TRAP (25 microM) at 0, 30, 60 and 90 min to measure max aggregation by LTA. Platelets not COLC-preincubated served as controls. Seven patients were pre-selected as clopidogrel non-responders. COLC significantly reduced TRAP-induced platelet aggregation in clopidogrel responders and non-responders. Interestingly, COLC inhibited ADP-induced platelet aggregation in clopidogrel non-responders in which ADP still caused activation despite DAPT. We demonstrate that COLC inhibits platelet aggregation in clopidogrel non-responders with HPR despite DAPT with this ADP receptor-inhibitor. Further in vivo studies should be designed to evaluate the opportunity to prescribe colchicine after ACS/CCS to overcome the clopidogrel limitations in the DAPT therapy. |*Percutaneous Coronary Intervention/adverse effects[MESH] |Aspirin/*therapeutic use[MESH] |Clopidogrel/*therapeutic use[MESH] |Colchicine/*pharmacology[MESH] |Drug Resistance[MESH] |Dual Anti-Platelet Therapy[MESH] |Humans[MESH] |Myocardial Ischemia/blood/diagnosis/*therapy[MESH] |Platelet Aggregation Inhibitors/*therapeutic use[MESH] |Platelet Aggregation/*drug effects[MESH] |Platelet Function Tests[MESH]Effects of colchicine on platelet aggregation in patients on dual anti(epmc).pdf DeepDyve Pubget Overpricing