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10.1016/j.meegid.2020.104330 http://scihub22266oqcxt.onion/10.1016/j.meegid.2020.104330 32335334!7180377!32335334     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Infect+Genet+Evol 2020 ; 84 (ä): 104330 Nephropedia Template TP {{tp|p=32335334|t=2020. Emerging genetic diversity among clinical isolates of SARS-CoV-2: Lessons for today |pdf=|usr=}}{{32335334}} gab.com Text Emerging genetic diversity among clinical isolates of SARS-CoV-2: Lessons for today JO: Infect Genet Evol http://www.kidney.de/pget.php?&tw=1&pmid=32335334 #FOAvip Considering the current pandemic of COVID-19, it is imperative to gauge the role of molecular divergence in SARS-CoV-2 with time, due to clinical and epidemiological concerns. Our analyses involving molecular phylogenetics is a step toward understanding the transmission clusters that can be correlated to pathophysiology of the disease to gain insight into virulence mechanism. As the infections are increasing rapidly, more divergence is expected followed possibly by viral adaptation. We could identify mutational hotspots which appear to be major drivers of diversity among strains, with RBD of spike protein emerging as the key region involved in interaction with ACE2 and consequently a major determinant of infection outcome. We believe that such molecular analyses correlated with clinical characteristics and host predisposition need to be evaluated at the earliest to understand viral adaptability, disease prognosis, and transmission dynamics. Twit Text FOAVip Emerging genetic diversity among clinical isolates of SARS-CoV-2: Lessons for today ????Infect Genet Evol http://www.kidney.de/pget.php?&tw=1&pmid=32335334 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32335334 #FOAvip English Wikipedia <ref>{{Cite pmid|32335334}}</ref> Emerging genetic diversity among clinical isolates of SARS-CoV-2: Lessons for today #MMPMID32335334 Sheikh JA; Singh J; Singh H; Jamal S; Khubaib M; Kohli S; Dobrindt U; Rahman SA; Ehtesham NZ; Hasnain SE Infect Genet Evol 2020[Oct]; 84 (ä): 104330 PMID32335334show ga Considering the current pandemic of COVID-19, it is imperative to gauge the role of molecular divergence in SARS-CoV-2 with time, due to clinical and epidemiological concerns. Our analyses involving molecular phylogenetics is a step toward understanding the transmission clusters that can be correlated to pathophysiology of the disease to gain insight into virulence mechanism. As the infections are increasing rapidly, more divergence is expected followed possibly by viral adaptation. We could identify mutational hotspots which appear to be major drivers of diversity among strains, with RBD of spike protein emerging as the key region involved in interaction with ACE2 and consequently a major determinant of infection outcome. We believe that such molecular analyses correlated with clinical characteristics and host predisposition need to be evaluated at the earliest to understand viral adaptability, disease prognosis, and transmission dynamics. |*Genetic Variation[MESH] |Adult[MESH] |Aged[MESH] |Betacoronavirus/*genetics/physiology[MESH] |COVID-19[MESH] |Computational Biology[MESH] |Coronavirus Infections/epidemiology/transmission/*virology[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Phylogeny[MESH] |Pneumonia, Viral/epidemiology/transmission/*virology[MESH] |SARS-CoV-2[MESH] |Sequence Deletion[MESH]Emerging genetic diversity among clinical isolates of SARS-CoV-2: Less(epmc).pdf DeepDyve Pubget Overpricing