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10.1016/j.jinf.2020.04.026

http://scihub22266oqcxt.onion/10.1016/j.jinf.2020.04.026
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32335173!7179496!32335173
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suck abstract from ncbi


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pmid32335173      J+Infect 2020 ; 81 (1): e61-e66
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  • How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review #MMPMID32335173
  • Minotti C; Tirelli F; Barbieri E; Giaquinto C; Dona D
  • J Infect 2020[Jul]; 81 (1): e61-e66 PMID32335173show ga
  • OBJECTIVES: SARS-CoV-2 infection has now a global resonance. Data on how COVID-19 is affecting immunocompromised patients are however few. With our study we aimed to systematically review the current knowledge on SARS-CoV-2 cases in children and adults with immunosuppression, to evaluate outcomes in this special population. METHODS: A systematic review of literature was carried out to identify relevant articles, searching the EMBASE, Medline, and Google Scholar databases. Studies reporting data on pre-defined outcomes and related to immunosuppressed adults and children with SARS-CoV-2 were included. RESULTS: Sixteen relevant articles were identified with 110 immunosuppressed patients, mostly presenting cancer, along with transplantation and immunodeficiency. Cancer was more often associated with a more severe course, but not necessarily with a bad prognosis. Our data show that both children and adults with immunosuppression seem to have a favorable disease course, as compared to the general population. CONCLUSION: Immunosuppressed patients with COVID-19 seem to be few in relation to the overall figures, and to present a favorable outcome as compared to other comorbidities. This might be explained by a hypothetical protective role of a weaker immune response, determining a milder disease presentation and thus underdiagnosis. Nevertheless, surveillance on this special population should be encouraged.
  • |*Betacoronavirus[MESH]
  • |*Immunocompromised Host[MESH]
  • |Adult[MESH]
  • |COVID-19[MESH]
  • |Child[MESH]
  • |Coronavirus Infections/*immunology[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*immunology[MESH]


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