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SARS-CoV-2 and DPP4 inhibition: Is it time to pray for Janus Bifrons? #MMPMID32335097
Pitocco D; Tartaglione L; Viti L; Di Leo M; Pontecorvi A; Caputo S
Diabetes Res Clin Pract 2020[May]; 163 (ä): 108162 PMID32335097show ga
Diabetes could be a risk factor for severity and mortality in patients with coronavirus disease 2019 COVID-19. It has been hypothesized that DPP4 inhibition, a therapy currently available for type 2 diabetes, might represent a target for decreasing the risk of the acute respiratory complications of the COVID-19 infection but (1) lack of demonstration of SARS-CoV2 binding to DPP4 (2) possible protective role of sDPP4 in Middle East respiratory Syndrome (MERS-CoV) (3) demonstrated inhibition and downregulation of DPP4 by HIV1 and MERS-CoV and (4) not exclusive role of the receptor binding in tropism of the Coronavirus family, support that DPP4 inhibition at present doesn't represent a plausible approach to mitigate COVID-19.
|COVID-19[MESH]
|Coronavirus Infections/*drug therapy[MESH]
|Diabetes Mellitus, Type 2/*drug therapy[MESH]
|Dipeptidyl Peptidase 4/*metabolism[MESH]
|Dipeptidyl-Peptidase IV Inhibitors/pharmacology/*therapeutic use[MESH]