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10.1016/j.ijid.2020.04.041

http://scihub22266oqcxt.onion/10.1016/j.ijid.2020.04.041
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32334118!7195003!32334118
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suck abstract from ncbi


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pmid32334118      Int+J+Infect+Dis 2020 ; 95 (ä): 332-339
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  • Clinical value of immune-inflammatory parameters to assess the severity of coronavirus disease 2019 #MMPMID32334118
  • Zhu Z; Cai T; Fan L; Lou K; Hua X; Huang Z; Gao G
  • Int J Infect Dis 2020[Jun]; 95 (ä): 332-339 PMID32334118show ga
  • OBJECTIVE: To explore the clinical value of immune-inflammatory markers to assess the severity of coronavirus disease 2019 (COVID-19). METHODS: 127 consecutive hospitalized patients with confirmed COVID-19 were enrolled in this study, and classified into non-severe and severe groups. Demographics, symptoms, underlying diseases and laboratory data were collected and assessed for predictive value. RESULTS: Of 127 COVID-19 patients, 16 cases (12.60%) were classified into the severe group. High level of interleukin-6 (IL-6), C-reaction protein (CRP) and hypertension were independent risk factors for the severity of COVID-19. The risk model based on IL-6, CRP and hypertension had the highest area under the receiver operator characteristic curve (AUROC). Additionally, the baseline IL-6 was positively correlated with other immune-inflammatory parameters and the dynamic change of IL-6 in the severe cases were parallel to the amelioration of the disease. CONCLUSION: Our study showed that high level of IL-6, CRP and hypertension were independent risk factors for assessing the severity of COVID-19. The risk model established upon IL-6, CRP and hypertension had the highest predictability in this study. Besides, IL-6 played a pivotal role in the severity of COVID-19 and had a potential value for monitoring the process of severe cases.
  • |*Betacoronavirus[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/etiology/*immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hypertension/complications[MESH]
  • |Interleukin-6/blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/etiology/*immunology[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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