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10.1016/j.cell.2020.04.004 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.04.004 32333836!7181998!32333836     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 181 (4): 905-913.e7 Nephropedia Template TP {{tp|p=32333836|t=2020. Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2 |pdf=|usr=}}{{32333836}} gab.com Text Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2 JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=32333836 #FOAvip We have previously provided the first genetic evidence that angiotensin converting enzyme 2 (ACE2) is the critical receptor for severe acute respiratory syndrome coronavirus (SARS-CoV), and ACE2 protects the lung from injury, providing a molecular explanation for the severe lung failure and death due to SARS-CoV infections. ACE2 has now also been identified as a key receptor for SARS-CoV-2 infections, and it has been proposed that inhibiting this interaction might be used in treating patients with COVID-19. However, it is not known whether human recombinant soluble ACE2 (hrsACE2) blocks growth of SARS-CoV-2. Here, we show that clinical grade hrsACE2 reduced SARS-CoV-2 recovery from Vero cells by a factor of 1,000-5,000. An equivalent mouse rsACE2 had no effect. We also show that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human kidney organoids, which can be inhibited by hrsACE2. These data demonstrate that hrsACE2 can significantly block early stages of SARS-CoV-2 infections. Twit Text FOAVip Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2 ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=32333836 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32333836 #FOAvip English Wikipedia <ref>{{Cite pmid|32333836}}</ref> Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2 #MMPMID32333836 Monteil V; Kwon H; Prado P; Hagelkruys A; Wimmer RA; Stahl M; Leopoldi A; Garreta E; Hurtado Del Pozo C; Prosper F; Romero JP; Wirnsberger G; Zhang H; Slutsky AS; Conder R; Montserrat N; Mirazimi A; Penninger JM Cell 2020[May]; 181 (4): 905-913.e7 PMID32333836show ga We have previously provided the first genetic evidence that angiotensin converting enzyme 2 (ACE2) is the critical receptor for severe acute respiratory syndrome coronavirus (SARS-CoV), and ACE2 protects the lung from injury, providing a molecular explanation for the severe lung failure and death due to SARS-CoV infections. ACE2 has now also been identified as a key receptor for SARS-CoV-2 infections, and it has been proposed that inhibiting this interaction might be used in treating patients with COVID-19. However, it is not known whether human recombinant soluble ACE2 (hrsACE2) blocks growth of SARS-CoV-2. Here, we show that clinical grade hrsACE2 reduced SARS-CoV-2 recovery from Vero cells by a factor of 1,000-5,000. An equivalent mouse rsACE2 had no effect. We also show that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human kidney organoids, which can be inhibited by hrsACE2. These data demonstrate that hrsACE2 can significantly block early stages of SARS-CoV-2 infections. |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Betacoronavirus/*drug effects/genetics/isolation & purification/ultrastructure[MESH] |Blood Vessels/virology[MESH] |COVID-19[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/*drug therapy[MESH] |Humans[MESH] |Kidney/cytology/virology[MESH] |Mice[MESH] |Organoids/virology[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/genetics/metabolism/*pharmacology[MESH] |Pneumonia, Viral/*drug therapy[MESH] |Receptors, Virus/metabolism[MESH] |Recombinant Proteins/*pharmacology[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/metabolism[MESH]Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using (epmc).pdf DeepDyve Pubget Overpricing