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10.3390/v12040473 http://scihub22266oqcxt.onion/10.3390/v12040473 32331321!7232318!32331321     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2020 ; 12 (4): ä Nephropedia Template TP {{tp|p=32331321|t=2020. Broadly Neutralizing Bovine Antibodies: Highly Effective New Tools against Evasive Pathogens?|pdf=|usr=}}{{32331321}} gab.com Text Broadly Neutralizing Bovine Antibodies: Highly Effective New Tools against Evasive Pathogens JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=32331321 #FOAvip Potent antibody-mediated neutralization is critical for an organism to combat the vast array of pathogens it will face during its lifetime. Due to the potential genetic diversity of some viruses, such as HIV-1 and influenza, standard neutralizing antibodies are often ineffective or easily evaded as their targets are masked or rapidly mutated. This has thwarted efforts to both prevent and treat HIV-1 infections and means that entirely new formulations are required to vaccinate against influenza each year. However, some rare antibodies isolated from infected individuals confer broad and potent neutralization. A subset of these broadly neutralizing antibodies possesses a long complementarity-determining 3 region of the immunoglobulin heavy chain (CDR H3). This feature generates unique antigen binding site configurations that can engage conserved but otherwise inaccessible epitope targets thus neutralizing many viral variants. Remarkably, ultralong CDR H3s are a common feature of the cow antibody repertoire and are encoded by a single variable, diversity, joining (VDJ) recombination that is extensively diversified prior to antigen exposure. Recently, it was shown that cows rapidly generate a broadly neutralizing response upon exposure to HIV-1 and this is primarily mediated by these novel ultralong antibody types. This review summarises the current knowledge of these unusual CDR H3 structures and discusses their known and potential future uses. Twit Text FOAVip Broadly Neutralizing Bovine Antibodies: Highly Effective New Tools against Evasive Pathogens ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=32331321 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32331321 #FOAvip English Wikipedia <ref>{{Cite pmid|32331321}}</ref> Broadly Neutralizing Bovine Antibodies: Highly Effective New Tools against Evasive Pathogens? #MMPMID32331321 Burke MJ; Stockley PG; Boyes J Viruses 2020[Apr]; 12 (4): ä PMID32331321show ga Potent antibody-mediated neutralization is critical for an organism to combat the vast array of pathogens it will face during its lifetime. Due to the potential genetic diversity of some viruses, such as HIV-1 and influenza, standard neutralizing antibodies are often ineffective or easily evaded as their targets are masked or rapidly mutated. This has thwarted efforts to both prevent and treat HIV-1 infections and means that entirely new formulations are required to vaccinate against influenza each year. However, some rare antibodies isolated from infected individuals confer broad and potent neutralization. A subset of these broadly neutralizing antibodies possesses a long complementarity-determining 3 region of the immunoglobulin heavy chain (CDR H3). This feature generates unique antigen binding site configurations that can engage conserved but otherwise inaccessible epitope targets thus neutralizing many viral variants. Remarkably, ultralong CDR H3s are a common feature of the cow antibody repertoire and are encoded by a single variable, diversity, joining (VDJ) recombination that is extensively diversified prior to antigen exposure. Recently, it was shown that cows rapidly generate a broadly neutralizing response upon exposure to HIV-1 and this is primarily mediated by these novel ultralong antibody types. This review summarises the current knowledge of these unusual CDR H3 structures and discusses their known and potential future uses. |Animals[MESH] |Antibodies, Monoclonal/chemistry/genetics/immunology[MESH] |Antibodies, Neutralizing/chemistry/genetics/*immunology[MESH] |Antibodies, Viral[MESH] |Cattle[MESH] |Complementarity Determining Regions[MESH] |Gene Rearrangement, B-Lymphocyte[MESH] |Host-Pathogen Interactions/*immunology[MESH] |Humans[MESH] |Neutralization Tests[MESH]Broadly Neutralizing Bovine Antibodies: Highly Effective New Tools aga(epmc).pdf DeepDyve Pubget Overpricing