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10.1111/ajt.15941

http://scihub22266oqcxt.onion/10.1111/ajt.15941
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32330343!7264777!32330343
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suck abstract from ncbi

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  • COVID-19 in solid organ transplant recipients: Initial report from the US epicenter #MMPMID32330343
  • Pereira MR; Mohan S; Cohen DJ; Husain SA; Dube GK; Ratner LE; Arcasoy S; Aversa MM; Benvenuto LJ; Dadhania DM; Kapur S; Dove LM; Brown RS Jr; Rosenblatt RE; Samstein B; Uriel N; Farr MA; Satlin M; Small CB; Walsh TJ; Kodiyanplakkal RP; Miko BA; Aaron JG; Tsapepas DS; Emond JC; Verna EC
  • Am J Transplant 2020[Jul]; 20 (7): 1800-1808 PMID32330343show ga
  • Solid organ transplant recipients may be at a high risk for SARS-CoV-2 infection and poor associated outcomes. We herein report our initial experience with solid organ transplant recipients with SARS-CoV-2 infection at two centers during the first 3 weeks of the outbreak in New York City. Baseline characteristics, clinical presentation, antiviral and immunosuppressive management were compared between patients with mild/moderate and severe disease (defined as ICU admission, intubation or death). Ninety patients were analyzed with a median age of 57 years. Forty-six were kidney recipients, 17 lung, 13 liver, 9 heart, and 5 dual-organ transplants. The most common presenting symptoms were fever (70%), cough (59%), and dyspnea (43%). Twenty-two (24%) had mild, 41 (46%) moderate, and 27 (30%) severe disease. Among the 68 hospitalized patients, 12% required non-rebreather and 35% required intubation. 91% received hydroxychloroquine, 66% azithromycin, 3% remdesivir, 21% tocilizumab, and 24% bolus steroids. Sixteen patients died (18% overall, 24% of hospitalized, 52% of ICU) and 37 (54%) were discharged. In this initial cohort, transplant recipients with COVID-19 appear to have more severe outcomes, although testing limitations likely led to undercounting of mild/asymptomatic cases. As this outbreak unfolds, COVID-19 has the potential to severely impact solid organ transplant recipients.
  • |*Transplant Recipients[MESH]
  • |Adenosine Monophosphate/analogs & derivatives/therapeutic use[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Alanine/analogs & derivatives/therapeutic use[MESH]
  • |Antibodies, Monoclonal, Humanized/therapeutic use[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Azithromycin/therapeutic use[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*complications/drug therapy/*epidemiology/mortality[MESH]
  • |Critical Care[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/therapeutic use[MESH]
  • |Immunosuppression[MESH]
  • |Immunosuppressive Agents/therapeutic use[MESH]
  • |Intensive Care Units[MESH]
  • |Intubation[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |New York City/epidemiology[MESH]
  • |Organ Transplantation/*adverse effects[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/*epidemiology/mortality[MESH]
  • |Respiration, Artificial[MESH]
  • |SARS-CoV-2[MESH]
  • |Steroids/therapeutic use[MESH]
  • |Treatment Outcome[MESH]
  • |United States[MESH]


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  • suck abstract from ncbi

    1800 7.20 2020