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  • A retrospective study of risk factors for severe acute respiratory syndrome coronavirus 2 infections in hospitalized adult patients #MMPMID32329978
  • Yao Q; Wang P; Wang X; Qie G; Meng M; Tong X; Bai X; Ding M; Liu W; Liu K; Chu Y
  • Pol Arch Intern Med 2020[May]; 130 (5): 390-399 PMID32329978show ga
  • INTRODUCTION: Coronavirus disease 2019 (COVID19) caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV2) infection spread worldwide. OBJECTIVES: The aim of the study was to identify the clinical characteristics and risk factors associated with severe incidence of SARS CoV2 infection. PATIENTS AND METHODS: All adult patients (median [IQR] age, 52 [37-58] years) consecutively admitted to the Dabieshan Medical Center from January 30, 2020 to February 11, 2020 were collected and reviewed. Only patients diagnosed with COVID19 according to the World Health Organization interim guidance were included in this retrospective cohort study. RESULTS: A total of 108 patients with COVID19 were retrospectively analyzed. Twentyfive patients (23.1%) developed severe disease, and of those 12 patients (48%) died. Advanced age, comorbidities (most commonly hypertension), higher blood leukocyte count, neutrophil count, higher Creactive protein level, Ddimer level, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and Sequential Organ Failure Assessment (SOFA) score were associated with greater risk of COVID19, and so were lower lymphocyte count and albumin level. Multivariable regress ion showed increasing odds of severe COVID19 associated with higher SOFA score (odds ratio [OR], 2.45; 95% CI, 1.302-4.608; P = 0.005), and lymphocyte count less than 0.8 x 109/l (OR, 9.017; 95% CI, 2.808-28.857; P <0.001) on admission. Higher SOFA score (OR, 2.402; 95% CI, 1.313-4.395; P = 0.004) on admission was identified as risk factor for inhospital death. CONCLUSIONS: Lymphocytopenia and a higher SOFA score on admission could help clinicians to identify patients at high risk for developing severe COVID19. More related studies are needed in the future.
  • |*Betacoronavirus[MESH]
  • |*Severity of Illness Index[MESH]
  • |Adult[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*diagnosis[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Multiple Organ Failure/*diagnosis/etiology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis[MESH]
  • |Prognosis[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Sepsis/diagnosis[MESH]

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  • suck abstract from ncbi

    390 5.130 2020