Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1111/jth.14871

http://scihub22266oqcxt.onion/10.1111/jth.14871
suck pdf from google scholar
32329231!7264501!32329231
unlimited free pdf from europmc32329231    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi


Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
pmid32329231      J+Thromb+Haemost 2020 ; 18 (6): 1320-1323
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Direct oral anticoagulant plasma levels striking increase in severe COVID-19 respiratory syndrome patients treated with antiviral agents: The Cremona experience #MMPMID32329231
  • Testa S; Prandoni P; Paoletti O; Morandini R; Tala M; Dellanoce C; Giorgi-Pierfranceschi M; Betti M; Danzi GB; Pan A; Palareti G
  • J Thromb Haemost 2020[Jun]; 18 (6): 1320-1323 PMID32329231show ga
  • BACKGROUND: Antiviral drugs are administered in patients with severe COVID-19 respiratory syndrome, including those treated with direct oral anticoagulants (DOACs). Concomitant administration of antiviral agents has the potential to increase their plasma concentration. A series of patients managed in the Cremona Thrombosis Center were admitted at Cremona Hospital for SARS-CoV-2 and started antiviral drugs without stopping DOAC therapy. DOAC plasma levels were measured in hospital and results compared with those recorded before hospitalization. METHODS: All consecutive patients on DOACs were candidates for administration of antiviral agents (lopinavir, ritonavir, or darunavir). Plasma samples for DOAC measurement were collected 2to 4 days after starting antiviral treatment, at 12 hours from the last dose intake in patients on dabigatran and apixaban, and at 24 hours in those on rivaroxaban and edoxaban. For each patient, C-trough DOAC level, expressed as ng/mL, was compared with the one measured before hospitalization. RESULTS: Of the 1039 patients hospitalized between February 22 and March 15, 2020 with COVID-19 pneumonia and candidates for antiviral therapy, 32 were on treatment with a DOAC. DOAC was stopped in 20 and continued in the remaining 12. On average, C-trough levels were 6.14 times higher during hospitalization than in the pre-hospitalization period. CONCLUSION: DOAC patients treated with antiviral drugs show an alarming increase in DOAC plasma levels. In order to prevent bleeding complications, we believe that physicians should consider withholding DOACs from patients with SARS-CoV-2 and replacing them with alternative parenteral antithrombotic strategies for as long as antiviral agents are deemed necessary and until discharge.
  • |Administration, Oral[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antithrombins/administration & dosage/adverse effects/*blood[MESH]
  • |Antiviral Agents/administration & dosage/*adverse effects[MESH]
  • |Betacoronavirus/*drug effects/pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/diagnosis/*drug therapy/virology[MESH]
  • |Dabigatran/administration & dosage/adverse effects/*blood[MESH]
  • |Darunavir/adverse effects[MESH]
  • |Drug Interactions[MESH]
  • |Drug Monitoring[MESH]
  • |Factor Xa Inhibitors/administration & dosage/adverse effects/*blood[MESH]
  • |Female[MESH]
  • |Hemorrhage/chemically induced[MESH]
  • |Humans[MESH]
  • |Italy[MESH]
  • |Lopinavir/adverse effects[MESH]
  • |Male[MESH]
  • |Pandemics[MESH]
  • |Patient Safety[MESH]
  • |Pneumonia, Viral/diagnosis/*drug therapy/virology[MESH]
  • |Pyrazoles/administration & dosage/adverse effects/*blood[MESH]
  • |Pyridines/administration & dosage/adverse effects/*blood[MESH]
  • |Pyridones/administration & dosage/adverse effects/*blood[MESH]
  • |Risk Assessment[MESH]
  • |Risk Factors[MESH]
  • |Ritonavir/adverse effects[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box