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10.1002/slct.201703052

http://scihub22266oqcxt.onion/10.1002/slct.201703052
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32328513!7169607!32328513
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suck abstract from ncbi


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pmid32328513      ChemistrySelect 2018 ; 3 (8): 2321-2325
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  • Selective Inhibition of Enterovirus A Species Members Reproduction by Furano 2, 3-d pyrimidine Nucleosides Revealed by Antiviral Activity Profiling against (+)ssRNA Viruses #MMPMID32328513
  • Kozlovskaya LI; Golinets AD; Eletskaya AA; Orlov AA; Palyulin VA; Kochetkov SN; Alexandrova LA; Osolodkin DI
  • ChemistrySelect 2018[Feb]; 3 (8): 2321-2325 PMID32328513show ga
  • The rational design of broad-spectrum antivirals requires data on antiviral activity of compounds against multiple viruses, which are often not available. We have developed a panel of (+)ssRNA viruses composed of Enterovirus and Flavivirus genera members allowing to study these activity spectra. Antiviral activity profiling of a set of nucleoside analogues revealed N (4)-hydroxycytidine as an efficient inhibitor of replication of coxsackieviruses and other enteroviruses, but ineffective against tick-borne encephalitis virus. Furano[2, 3-d]pyrimidine nucleosides with n-pentyl or n-hexyl tails showed selective inhibition of Enterovirus A representatives. 5-(Tetradec-1-yn-1-yl)-uridine showed selective inhibition of tick-borne encephalitis virus at the micromolar level.
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