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10.1038/s41420-020-0262-7 http://scihub22266oqcxt.onion/10.1038/s41420-020-0262-7 32328292!7168568!32328292     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Discov 2020 ; 6 (ä): 24 Nephropedia Template TP {{tp|p=32328292|t=2020. HSD11B1 is upregulated synergistically by IFNgamma and TNFalpha and mediates TSG-6 expression in human UC-MSCs |pdf=|usr=}}{{32328292}} gab.com Text HSD11B1 is upregulated synergistically by IFNgamma and TNFalpha and mediates TSG-6 expression in human UC-MSCs JO: Cell Death Discov http://www.kidney.de/pget.php?&tw=1&pmid=32328292 #FOAvip Inflammatory factors such as IFNgamma and TNFalpha could endow mesenchymal stem cells (MSCs) a potent immunomodulatory property, a process called licensing, but the mechanisms are not fully understood. We here found that glucocorticoid-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1), which converts inactive cortisone to the active cortisol and thereby regulates tissue glucocorticoid (GC) levels, was greatly upregulated by IFNgamma and TNFalpha in human umbilical cord-derived MSCs (UC-MSCs) in a synergistic manner. While IFNgamma alone was not able to induce HSD11B1, it could increase the activity of NF-kB and thus augment the upregulation of HSD11B1 by TNFalpha. Interestingly, the upregulation of HSD11B1 by IFNgamma and TNFalpha also required glucocorticoid receptor. Furthermore, HSD11B1 was shown to be required for the expression of TNF-stimulated gene 6 (TSG-6), an important anti-inflammatory effector molecule of MSCs. Therefore, the inflammatory factors IFNgamma and TNFalpha can promote GC metabolism and thereby drive the expression of anti-inflammatory factor TSG-6 in human UC-MSCs, forming a potential negative feedback loop. These findings help to understand the relationship between inflammation and GC metabolism. Twit Text FOAVip HSD11B1 is upregulated synergistically by IFNgamma and TNFalpha and mediates TSG-6 expression in human UC-MSCs ????Cell Death Discov http://www.kidney.de/pget.php?&tw=1&pmid=32328292 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32328292 #FOAvip English Wikipedia <ref>{{Cite pmid|32328292}}</ref> HSD11B1 is upregulated synergistically by IFNgamma and TNFalpha and mediates TSG-6 expression in human UC-MSCs #MMPMID32328292 Huang P; Li Y; Xu C; Melino G; Shao C; Shi Y Cell Death Discov 2020[]; 6 (ä): 24 PMID32328292show ga Inflammatory factors such as IFNgamma and TNFalpha could endow mesenchymal stem cells (MSCs) a potent immunomodulatory property, a process called licensing, but the mechanisms are not fully understood. We here found that glucocorticoid-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1), which converts inactive cortisone to the active cortisol and thereby regulates tissue glucocorticoid (GC) levels, was greatly upregulated by IFNgamma and TNFalpha in human umbilical cord-derived MSCs (UC-MSCs) in a synergistic manner. While IFNgamma alone was not able to induce HSD11B1, it could increase the activity of NF-kB and thus augment the upregulation of HSD11B1 by TNFalpha. Interestingly, the upregulation of HSD11B1 by IFNgamma and TNFalpha also required glucocorticoid receptor. Furthermore, HSD11B1 was shown to be required for the expression of TNF-stimulated gene 6 (TSG-6), an important anti-inflammatory effector molecule of MSCs. Therefore, the inflammatory factors IFNgamma and TNFalpha can promote GC metabolism and thereby drive the expression of anti-inflammatory factor TSG-6 in human UC-MSCs, forming a potential negative feedback loop. These findings help to understand the relationship between inflammation and GC metabolism. äHSD11B1 is upregulated synergistically by IFNgamma and TNFalpha and me(epmc).pdf DeepDyve Pubget Overpricing