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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Med 2020 ; 26 (5): 681-687 Nephropedia Template TP
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SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes #MMPMID32327758
Sungnak W; Huang N; Becavin C; Berg M; Queen R; Litvinukova M; Talavera-Lopez C; Maatz H; Reichart D; Sampaziotis F; Worlock KB; Yoshida M; Barnes JL
Nat Med 2020[May]; 26 (5): 681-687 PMID32327758show ga
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.