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10.3390/nu12041140 http://scihub22266oqcxt.onion/10.3390/nu12041140 32325790!7230898!32325790     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nutrients 2020 ; 12 (4): ä Nephropedia Template TP {{tp|p=32325790|t=2020. Key Vitamin D Target Genes with Functions in the Immune System |pdf=|usr=}}{{32325790}} gab.com Text Key Vitamin D Target Genes with Functions in the Immune System JO: Nutrients http://www.kidney.de/pget.php?&tw=1&pmid=32325790 #FOAvip The biologically active form of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), modulates innate and adaptive immunity via genes regulated by the transcription factor vitamin D receptor (VDR). In order to identify the key vitamin D target genes involved in these processes, transcriptome-wide datasets were compared, which were obtained from a human monocytic cell line (THP-1) and peripheral blood mononuclear cells (PBMCs) treated in vitro by 1,25(OH)(2)D(3), filtered using different approaches, as well as from PBMCs of individuals supplemented with a vitamin D(3) bolus. The led to the genes ACVRL1, CAMP, CD14, CD93, CEBPB, FN1, MAPK13, NINJ1, LILRB4, LRRC25, SEMA6B, SRGN, THBD, THEMIS2 and TREM1. Public epigenome- and transcriptome-wide data from THP-1 cells were used to characterize these genes based on the level of their VDR-driven enhancers as well as the level of the dynamics of their mRNA production. Both types of datasets allowed the categorization of the vitamin D target genes into three groups according to their role in (i) acute response to infection, (ii) infection in general and (iii) autoimmunity. In conclusion, 15 genes were identified as major mediators of the action of vitamin D in innate and adaptive immunity and their individual functions are explained based on different gene regulatory scenarios. Twit Text FOAVip Key Vitamin D Target Genes with Functions in the Immune System ????Nutrients http://www.kidney.de/pget.php?&tw=1&pmid=32325790 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32325790 #FOAvip English Wikipedia <ref>{{Cite pmid|32325790}}</ref> Key Vitamin D Target Genes with Functions in the Immune System #MMPMID32325790 Koivisto O; Hanel A; Carlberg C Nutrients 2020[Apr]; 12 (4): ä PMID32325790show ga The biologically active form of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), modulates innate and adaptive immunity via genes regulated by the transcription factor vitamin D receptor (VDR). In order to identify the key vitamin D target genes involved in these processes, transcriptome-wide datasets were compared, which were obtained from a human monocytic cell line (THP-1) and peripheral blood mononuclear cells (PBMCs) treated in vitro by 1,25(OH)(2)D(3), filtered using different approaches, as well as from PBMCs of individuals supplemented with a vitamin D(3) bolus. The led to the genes ACVRL1, CAMP, CD14, CD93, CEBPB, FN1, MAPK13, NINJ1, LILRB4, LRRC25, SEMA6B, SRGN, THBD, THEMIS2 and TREM1. Public epigenome- and transcriptome-wide data from THP-1 cells were used to characterize these genes based on the level of their VDR-driven enhancers as well as the level of the dynamics of their mRNA production. Both types of datasets allowed the categorization of the vitamin D target genes into three groups according to their role in (i) acute response to infection, (ii) infection in general and (iii) autoimmunity. In conclusion, 15 genes were identified as major mediators of the action of vitamin D in innate and adaptive immunity and their individual functions are explained based on different gene regulatory scenarios. |Activin Receptors, Type II[MESH] |Adaptive Immunity/*genetics[MESH] |Antimicrobial Cationic Peptides[MESH] |Autoimmunity/genetics/immunology[MESH] |CCAAT-Enhancer-Binding Protein-beta[MESH] |Cathelicidins[MESH] |Datasets as Topic[MESH] |Fibronectins[MESH] |Gene Expression Regulation/*genetics/*immunology[MESH] |Humans[MESH] |Immunity, Innate/*genetics[MESH] |Leukocytes, Mononuclear/immunology[MESH] |Lipopolysaccharide Receptors[MESH] |Membrane Glycoproteins[MESH] |Receptors, Calcitriol/*physiology[MESH] |Receptors, Complement[MESH] |THP-1 Cells/immunology[MESH] |Transcriptome[MESH]Key Vitamin D Target Genes with Functions in the Immune System (epmc).pdf DeepDyve Pubget Overpricing