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10.3390/nu12041139

http://scihub22266oqcxt.onion/10.3390/nu12041139
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32325778!7230517!32325778
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suck abstract from ncbi


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pmid32325778      Nutrients 2020 ; 12 (4): ä
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  • Effects of an Omega-3 and Vitamin D Supplement on Fatty Acids and Vitamin D Serum Levels in Double-Blinded, Randomized, Controlled Trials in Healthy and Crohn s Disease Populations #MMPMID32325778
  • Brennan Laing B; Cavadino A; Ellett S; Ferguson LR
  • Nutrients 2020[Apr]; 12 (4): ä PMID32325778show ga
  • Two trials separately measured the bioavailability and impact on inflammation of a supplement taken daily containing 510 mg Docosahexaenoic acid (DHA), 344 mg Eicosapentaenoic acid (EPA), and 1000 IU of vitamin D (25-hydroxyvitamin D; 25(OH)D), for healthy and Crohn's disease (CD) populations. Both trials were double blinded, randomized, placebo-controlled with cross-over. Participants were randomly allocated to groups A (placebo then supplement) or B (supplement then placebo). Both included a washout. Fatty acid (N-3 PUFAs) and vitamin D serum levels, plasma C-reactive protein (CRP), and stool calprotectin were measured before and after each treatment period. Outcome measures were analyzed using generalized linear mixed models, including terms for treatment, period, and a treatment-by-period interaction. The supplement significantly increased serum levels in healthy and CD groups for EPA (p < 0.001 and p < 0.001, respectively), Docosapentaenoic acid (p < 0.001 and 0.005), DHA (p < 0.001 and 0.006), the omega-3 index (p < 0.001 and 0.001), and (vitamin D (p < 0.001 and 0.027). CRP and calprotectin measures showed no evidence of a treatment effect on inflammation; however, model estimation was imprecise for both outcomes, hence further research is required to elucidate potential inflammation effects. The nutrient supplement increased serum levels of key N-3 PUFAs and vitamin D in both populations, showing the preparation was readily bioavailable.
  • |*Dietary Supplements[MESH]
  • |*Healthy Volunteers[MESH]
  • |Adult[MESH]
  • |Biological Availability[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |Crohn Disease/*blood[MESH]
  • |Cross-Over Studies[MESH]
  • |Docosahexaenoic Acids/administration & dosage[MESH]
  • |Double-Blind Method[MESH]
  • |Eicosapentaenoic Acid/administration & dosage[MESH]
  • |Fatty Acids, Omega-3/*administration & dosage[MESH]
  • |Fatty Acids/*blood[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Inflammation[MESH]
  • |Leukocyte L1 Antigen Complex/analysis[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nutritional Physiological Phenomena/*physiology[MESH]


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