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10.1016/j.bcmd.2020.102437 http://scihub22266oqcxt.onion/10.1016/j.bcmd.2020.102437 32325421!7194879!32325421     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Blood+Cells+Mol+Dis 2020 ; 83 (ä): 102437 Nephropedia Template TP {{tp|p=32325421|t=2020. Increased expression of CD8 marker on T-cells in COVID-19 patients |pdf=|usr=}}{{32325421}} gab.com Text Increased expression of CD8 marker on T-cells in COVID-19 patients JO: Blood Cells Mol Dis http://www.kidney.de/pget.php?&tw=1&pmid=32325421 #FOAvip BACKGROUND: Cell-mediated immunity including T-cells (T helper and cytotoxic) plays an essential role in efficient antiviral responses against coronavirus disease-2019 (COVID-19). Therefore, in this study, we evaluated the ratio and expression of CD4 and CD8 markers in COVID-19 patients to clarify the immune characterizations of CD4 and CD8 T-cells in COVID-19 patients. METHODS: Peripheral blood samples of 25 COVID-19 patients and 25 normal individuals with similar age and sex as the control group were collected. White blood cells, platelets, and lymphocytes were counted and CD4 and CD8 T lymphocytes were evaluated by flow cytometry. RESULTS: The number of white blood cells, lymphocytes, and platelets were reduced significantly in COVID-19 patients (P < 0.05). The difference in CD4:CD8 ratio, CD4 T-cell frequency, CD8 T-cell frequency, and CD4 mean fluorescence intensity (MFI) was not significant between COVID-19 patients and healthy individuals (P > 0.05); however, the CD8 MFI increased significantly in COVID-19 infected patients (P < 0.05). CONCLUSION: Although, there is no significant difference in the ratio of CD4 to CD8 between two groups, the expression level of CD8 in COVID-19 patients was significantly higher than the normal individuals. This result suggested that the cellular immune responses triggered by COVID-19 infection were developed through overexpression of CD8 and hyperactivation of cytotoxic T lymphocytes. Twit Text FOAVip Increased expression of CD8 marker on T-cells in COVID-19 patients ????Blood Cells Mol Dis http://www.kidney.de/pget.php?&tw=1&pmid=32325421 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32325421 #FOAvip English Wikipedia <ref>{{Cite pmid|32325421}}</ref> Increased expression of CD8 marker on T-cells in COVID-19 patients #MMPMID32325421 Ganji A; Farahani I; Khansarinejad B; Ghazavi A; Mosayebi G Blood Cells Mol Dis 2020[Jul]; 83 (ä): 102437 PMID32325421show ga BACKGROUND: Cell-mediated immunity including T-cells (T helper and cytotoxic) plays an essential role in efficient antiviral responses against coronavirus disease-2019 (COVID-19). Therefore, in this study, we evaluated the ratio and expression of CD4 and CD8 markers in COVID-19 patients to clarify the immune characterizations of CD4 and CD8 T-cells in COVID-19 patients. METHODS: Peripheral blood samples of 25 COVID-19 patients and 25 normal individuals with similar age and sex as the control group were collected. White blood cells, platelets, and lymphocytes were counted and CD4 and CD8 T lymphocytes were evaluated by flow cytometry. RESULTS: The number of white blood cells, lymphocytes, and platelets were reduced significantly in COVID-19 patients (P < 0.05). The difference in CD4:CD8 ratio, CD4 T-cell frequency, CD8 T-cell frequency, and CD4 mean fluorescence intensity (MFI) was not significant between COVID-19 patients and healthy individuals (P > 0.05); however, the CD8 MFI increased significantly in COVID-19 infected patients (P < 0.05). CONCLUSION: Although, there is no significant difference in the ratio of CD4 to CD8 between two groups, the expression level of CD8 in COVID-19 patients was significantly higher than the normal individuals. This result suggested that the cellular immune responses triggered by COVID-19 infection were developed through overexpression of CD8 and hyperactivation of cytotoxic T lymphocytes. |*Immunity, Cellular[MESH] |Betacoronavirus/*immunology/isolation & purification[MESH] |Biomarkers/analysis[MESH] |CD4-CD8 Ratio[MESH] |CD8 Antigens/analysis/*immunology[MESH] |CD8-Positive T-Lymphocytes/*immunology/virology[MESH] |COVID-19[MESH] |Coronavirus Infections/blood/diagnosis/*immunology/virology[MESH] |Female[MESH] |Humans[MESH] |Lymphocyte Count[MESH] |Male[MESH] |Pandemics[MESH] |Platelet Count[MESH] |Pneumonia, Viral/blood/diagnosis/*immunology/virology[MESH]Increased expression of CD8 marker on T-cells in COVID-19 patients (epmc).pdf DeepDyve Pubget Overpricing