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10.1016/j.jinf.2020.04.001

http://scihub22266oqcxt.onion/10.1016/j.jinf.2020.04.001
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32325129!7169899!32325129
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suck abstract from ncbi


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pmid32325129      J+Infect 2020 ; 81 (1): 115-120
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  • The profile of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus pneumonia #MMPMID32325129
  • Li H; Chen K; Liu M; Xu H; Xu Q
  • J Infect 2020[Jul]; 81 (1): 115-120 PMID32325129show ga
  • OBJECTIVES: The study was aimed at investigating the characteristics of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus (2019-nCoV) pneumonia. METHODS: Children with 2019-nCoV pneumonia or with respiratory syncytial virus (RSV) pneumonia were included. Data including lymphocyte subsets and serum cytokines were collected and analyzed. RESULTS: 56 patients were included in the study, 40 children with 2019-nCoV pneumonia and 16 children with RSV pneumonia. Compared with children with RSV pneumonia, patients with 2019-nCoV pneumonia had higher count of CD3+8+ lymphocyte, higher percentages of CD3+, CD3+8+ lymphocytes and a lower percentage of CD19+ lymphocyte. The serum IL-10 level was significantly higher in children with RSV pneumonia. One 2019-nCoV pneumonia child who was with an obvious increase of IL-10 developed severe pneumonia. CONCLUSIONS: Immune response played a very important role in the development of 2019-nCoV pneumonia. The effective CD8+ T cell response might influence the severity of 2019-nCoV pneumonia. The adaptable change in IL-10 level might contribute to the relatively mild pneumonia symptoms in children with 2019-nCoV pneumonia and bacterial co-infection might be a risk factor of severe 2019-nCoV pneumonia.
  • |*Betacoronavirus[MESH]
  • |*Lymphocyte Count[MESH]
  • |*T-Lymphocyte Subsets[MESH]
  • |COVID-19[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Coronavirus Infections/*blood/immunology[MESH]
  • |Cytokines/*blood[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Male[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*blood/immunology[MESH]
  • |Respiratory Syncytial Virus Infections/blood/immunology[MESH]


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