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10.1016/j.drudis.2020.04.010

http://scihub22266oqcxt.onion/10.1016/j.drudis.2020.04.010
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32325124!7169894!32325124
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suck abstract from ncbi


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pmid32325124      Drug+Discov+Today 2020 ; 25 (6): 956-958
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  • Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals #MMPMID32325124
  • Manning TJ; Thomas-Richardson J; Cowan M; Beard T
  • Drug Discov Today 2020[Jun]; 25 (6): 956-958 PMID32325124show ga
  • This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural product extract as opposed to a single molecule as an antiviral agent; and (iii) a counter intuitive approach to formulation that is, in part, based on delivering multiple species that fall into three categories: building blocks for the virus to accelerate replication; an energy source for the infected cell to boost its immune response; and the species that antagonize or provide toxicity to the virus.
  • |Adenosine Monophosphate/administration & dosage/analogs & derivatives/chemistry[MESH]
  • |Alanine/administration & dosage/analogs & derivatives/chemistry[MESH]
  • |Antiviral Agents/*administration & dosage/*chemistry[MESH]
  • |Aquatic Organisms/*chemistry[MESH]
  • |Biological Products/*administration & dosage/*chemistry[MESH]
  • |COVID-19[MESH]
  • |Chloroquine/administration & dosage/chemistry[MESH]
  • |Coronavirus Infections/drug therapy[MESH]
  • |Drug Compounding[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/administration & dosage/chemistry[MESH]
  • |Models, Molecular[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/drug therapy[MESH]


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