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Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals #MMPMID32325124
Manning TJ; Thomas-Richardson J; Cowan M; Beard T
Drug Discov Today 2020[Jun]; 25 (6): 956-958 PMID32325124show ga
This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural product extract as opposed to a single molecule as an antiviral agent; and (iii) a counter intuitive approach to formulation that is, in part, based on delivering multiple species that fall into three categories: building blocks for the virus to accelerate replication; an energy source for the infected cell to boost its immune response; and the species that antagonize or provide toxicity to the virus.
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Drug+Discov+Today 2020 ; 25 (6): 956-958
