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10.5582/ddt.2020.03010 http://scihub22266oqcxt.onion/10.5582/ddt.2020.03010 32321878!ä!32321878 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Drug+Discov+Ther 2020 ; 14 (2): 107-108 Nephropedia Template TP {{tp|p=32321878|t=2020. Is GSK3beta a molecular target of chloroquine treatment against COVID-19?|pdf=|usr=}}{{32321878}} gab.com Text Is GSK3beta a molecular target of chloroquine treatment against COVID-19 JO: Drug Discov Ther http://www.kidney.de/pget.php?&tw=1&pmid=32321878 #FOAvip The recent clinical trial reports pertaining to the efficacy of chloroquine and hydroxychloroquine against COVID-19 albeit yet to be validated with larger clinical trials, have sparked much interest globally to evaluate whether this anti-malarial drug can be repurposed for the treatment of COVID-19. In addition to its anti-viral activity, the anti-inflammatory activity of chloroquine may also contribute to its efficacy. Based on our data obtained from an animal infection model of melioidosis (a disease caused by the bacteria Burkholderia pseudomallei), treatment with chloroquine can result in the phosphorylation and consequent inhibition of glycogen synthase kinase-3beta (GSK3beta). This serine/threonine protein kinase is now recognised as a point of convergence for host inflammatory response. In view of this, it is plausible that the mechanism for the anti-inflammatory effect of chloroquine against COVID-19 involves inhibition of host GSK3beta. Twit Text FOAVip Is GSK3beta a molecular target of chloroquine treatment against COVID-19 ????Drug Discov Ther http://www.kidney.de/pget.php?&tw=1&pmid=32321878 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32321878 #FOAvip English Wikipedia <ref>{{Cite pmid|32321878}}</ref> Is GSK3beta a molecular target of chloroquine treatment against COVID-19? #MMPMID32321878 Embi MN; Ganesan N; Sidek HM Drug Discov Ther 2020[May]; 14 (2): 107-108 PMID32321878show ga The recent clinical trial reports pertaining to the efficacy of chloroquine and hydroxychloroquine against COVID-19 albeit yet to be validated with larger clinical trials, have sparked much interest globally to evaluate whether this anti-malarial drug can be repurposed for the treatment of COVID-19. In addition to its anti-viral activity, the anti-inflammatory activity of chloroquine may also contribute to its efficacy. Based on our data obtained from an animal infection model of melioidosis (a disease caused by the bacteria Burkholderia pseudomallei), treatment with chloroquine can result in the phosphorylation and consequent inhibition of glycogen synthase kinase-3beta (GSK3beta). This serine/threonine protein kinase is now recognised as a point of convergence for host inflammatory response. In view of this, it is plausible that the mechanism for the anti-inflammatory effect of chloroquine against COVID-19 involves inhibition of host GSK3beta. |Animals[MESH] |Anti-Inflammatory Agents/therapeutic use[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Chloroquine/*therapeutic use[MESH] |Coronavirus Infections/*drug therapy[MESH] |Disease Models, Animal[MESH] |Glycogen Synthase Kinase 3 beta/*antagonists & inhibitors[MESH] |Melioidosis/drug therapy[MESH] |Pandemics[MESH] |Phosphorylation[MESH] |Pneumonia, Viral/*drug therapy[MESH]Is GSK3beta a molecular target of chloroquine treatment against COVID-(epmc).pdf DeepDyve Pubget Overpricing