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10.1016/j.chom.2020.04.009 http://scihub22266oqcxt.onion/10.1016/j.chom.2020.04.009 32320677!7172841!32320677     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32320677&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2020 ; 27 (6): 992-1000.e3 Nephropedia Template TP {{tp|p=32320677|t=2020. Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure |pdf=|usr=}}{{32320677}} gab.com Text Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=32320677 #FOAvip Proper management of COVID-19 mandates better understanding of disease pathogenesis. The sudden clinical deterioration 7-8 days after initial symptom onset suggests that severe respiratory failure (SRF) in COVID-19 is driven by a unique pattern of immune dysfunction. We studied immune responses of 54 COVID-19 patients, 28 of whom had SRF. All patients with SRF displayed either macrophage activation syndrome (MAS) or very low human leukocyte antigen D related (HLA-DR) expression accompanied by profound depletion of CD4 lymphocytes, CD19 lymphocytes, and natural killer (NK) cells. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) production by circulating monocytes was sustained, a pattern distinct from bacterial sepsis or influenza. SARS-CoV-2 patient plasma inhibited HLA-DR expression, and this was partially restored by the IL-6 blocker Tocilizumab; off-label Tocilizumab treatment of patients was accompanied by increase in circulating lymphocytes. Thus, the unique pattern of immune dysregulation in severe COVID-19 is characterized by IL-6-mediated low HLA-DR expression and lymphopenia, associated with sustained cytokine production and hyper-inflammation. Twit Text FOAVip Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=32320677 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32320677 #FOAvip English Wikipedia <ref>{{Cite pmid|32320677}}</ref> Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure #MMPMID32320677 Giamarellos-Bourboulis EJ; Netea MG; Rovina N; Akinosoglou K; Antoniadou A; Antonakos N; Damoraki G; Gkavogianni T; Adami ME; Katsaounou P; Ntaganou M; Kyriakopoulou M; Dimopoulos G; Koutsodimitropoulos I; Velissaris D; Koufargyris P; Karageorgos A; Katrini K; Lekakis V; Lupse M; Kotsaki A; Renieris G; Theodoulou D; Panou V; Koukaki E; Koulouris N; Gogos C; Koutsoukou A Cell Host Microbe 2020[Jun]; 27 (6): 992-1000.e3 PMID32320677show ga Proper management of COVID-19 mandates better understanding of disease pathogenesis. The sudden clinical deterioration 7-8 days after initial symptom onset suggests that severe respiratory failure (SRF) in COVID-19 is driven by a unique pattern of immune dysfunction. We studied immune responses of 54 COVID-19 patients, 28 of whom had SRF. All patients with SRF displayed either macrophage activation syndrome (MAS) or very low human leukocyte antigen D related (HLA-DR) expression accompanied by profound depletion of CD4 lymphocytes, CD19 lymphocytes, and natural killer (NK) cells. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) production by circulating monocytes was sustained, a pattern distinct from bacterial sepsis or influenza. SARS-CoV-2 patient plasma inhibited HLA-DR expression, and this was partially restored by the IL-6 blocker Tocilizumab; off-label Tocilizumab treatment of patients was accompanied by increase in circulating lymphocytes. Thus, the unique pattern of immune dysregulation in severe COVID-19 is characterized by IL-6-mediated low HLA-DR expression and lymphopenia, associated with sustained cytokine production and hyper-inflammation. |Aged[MESH] |Antibodies, Monoclonal, Humanized/administration & dosage[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology/*pathology[MESH] |Female[MESH] |HLA-DR Antigens/immunology[MESH] |Humans[MESH] |Inflammation/pathology[MESH] |Interleukin-6/immunology[MESH] |Killer Cells, Natural/pathology[MESH] |Lymphopenia/pathology[MESH] |Macrophage Activation[MESH] |Male[MESH] |Monocytes/pathology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/*pathology[MESH]Complex Immune Dysregulation in COVID-19 Patients with Severe Respirat(epmc).pdf DeepDyve Pubget Overpricing