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10.1111/ene.14273

http://scihub22266oqcxt.onion/10.1111/ene.14273
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32320508!7264557!32320508
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suck abstract from ncbi


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pmid32320508      Eur+J+Neurol 2020 ; 27 (9): 1738-1741
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  • Acute-onset smell and taste disorders in the context of COVID-19: a pilot multicentre polymerase chain reaction based case-control study #MMPMID32320508
  • Beltran-Corbellini A; Chico-Garcia JL; Martinez-Poles J; Rodriguez-Jorge F; Natera-Villalba E; Gomez-Corral J; Gomez-Lopez A; Monreal E; Parra-Diaz P; Cortes-Cuevas JL; Galan JC; Fragola-Arnau C; Porta-Etessam J; Masjuan J; Alonso-Canovas A
  • Eur J Neurol 2020[Sep]; 27 (9): 1738-1741 PMID32320508show ga
  • BACKGROUND AND PURPOSE: Specific respiratory tract infections, including COVID-19, may cause smell and/or taste disorders (STDs) with increased frequency. The aim was to determine whether new-onset STDs are more frequent amongst COVID-19 patients than influenza patients. METHOD: This was a case-control study including hospitalized patients of two tertiary care centres. Consecutive patients positive for COVID-19 polymerase chain reaction (cases) and patients positive for influenza polymerase chain reaction (historical control sample) were assessed during specific periods, employing a self-reported STD questionnaire. RESULTS: Seventy-nine cases and 40 controls were included. No significant differences were found in basal features between the two groups. New-onset STDs were significantly more frequent amongst cases (31, 39.2%) than in the control group (5, 12.5 %) [adjusted odds ratio 21.4 (2.77-165.4, P = 0.003)]. COVID-19 patients with new-onset STDs were significantly younger than COVID-19 patients without STDs (52.6 +/- 17.2 vs. 67.4 +/- 15.1, P < 0.001). Amongst COVID-19 patients who presented STDs, 22 (70.9%) recalled an acute onset and it was an initial manifestation in 11 (35.5%). Twenty-five (80.6%) presented smell disorders (mostly anosmia, 14, 45.2%) and 28 (90.3%) taste disorders (mostly ageusia, 14, 45.2%). Only four (12.9 %) reported concomitant nasal obstruction. The mean duration of STD was 7.5 +/- 3.2 days and 12 patients (40%) manifested complete recovery after 7.4 +/- 2.3 days of onset. CONCLUSION: New-onset STDs were significantly more frequent amongst COVID-19 patients than influenza patients; they usually had an acute onset and were commonly an initial manifestation. The use of STD assessment in anamnesis as a hint for COVID-19 and to support individuals' self-isolation in the current epidemic context is suggested.
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19/*complications[MESH]
  • |Case-Control Studies[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Incidence[MESH]
  • |Influenza, Human/*complications[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Olfaction Disorders/*epidemiology/etiology[MESH]
  • |Pandemics[MESH]
  • |Polymerase Chain Reaction[MESH]
  • |Self Report[MESH]
  • |Surveys and Questionnaires[MESH]


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