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10.1002/cpt.1863 http://scihub22266oqcxt.onion/10.1002/cpt.1863 32320478!7264499!32320478     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Pharmacol+Ther 2020 ; 108 (2): 236-241 Nephropedia Template TP {{tp|p=32320478|t=2020. Risks of ACE Inhibitor and ARB Usage in COVID-19: Evaluating the Evidence |pdf=|usr=}}{{32320478}} gab.com Text Risks of ACE Inhibitor and ARB Usage in COVID-19: Evaluating the Evidence JO: Clin Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=32320478 #FOAvip Concerns have been raised regarding the safety of angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in patients with coronavirus disease of 2019 (COVID-19), based on the hypothesis that such medications may raise expression of ACE2, the receptor for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). We conducted a literature review of studies (n = 12) in experimental animals and human subjects (n = 12) and evaluated the evidence regarding the impact of administration of ACEIs and ARBs on ACE2 expression. We prioritized studies that assessed ACE2 protein expression data, measured directly or inferred from ACE2 activity assays. The findings in animals are inconsistent with respect to an increase in ACE2 expression in response to treatment with ACEIs or ARBs. Control/sham animals show little to no effect in the plurality of studies. Those studies that report increases in ACE2 expression tend to involve acute injury models and/or higher doses of ACEIs or ARBs than are typically administered to patients. Data from human studies overwhelmingly imply that administration of ACEIs/ARBs does not increase ACE2 expression. Available evidence, in particular, data from human studies, does not support the hypothesis that ACEI/ARB use increases ACE2 expression and the risk of complications from COVID-19. We conclude that patients being treated with ACEIs and ARBs should continue their use for approved indications. Twit Text FOAVip Risks of ACE Inhibitor and ARB Usage in COVID-19: Evaluating the Evidence ????Clin Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=32320478 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32320478 #FOAvip English Wikipedia <ref>{{Cite pmid|32320478}}</ref> Risks of ACE Inhibitor and ARB Usage in COVID-19: Evaluating the Evidence #MMPMID32320478 Sriram K; Insel PA Clin Pharmacol Ther 2020[Aug]; 108 (2): 236-241 PMID32320478show ga Concerns have been raised regarding the safety of angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in patients with coronavirus disease of 2019 (COVID-19), based on the hypothesis that such medications may raise expression of ACE2, the receptor for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). We conducted a literature review of studies (n = 12) in experimental animals and human subjects (n = 12) and evaluated the evidence regarding the impact of administration of ACEIs and ARBs on ACE2 expression. We prioritized studies that assessed ACE2 protein expression data, measured directly or inferred from ACE2 activity assays. The findings in animals are inconsistent with respect to an increase in ACE2 expression in response to treatment with ACEIs or ARBs. Control/sham animals show little to no effect in the plurality of studies. Those studies that report increases in ACE2 expression tend to involve acute injury models and/or higher doses of ACEIs or ARBs than are typically administered to patients. Data from human studies overwhelmingly imply that administration of ACEIs/ARBs does not increase ACE2 expression. Available evidence, in particular, data from human studies, does not support the hypothesis that ACEI/ARB use increases ACE2 expression and the risk of complications from COVID-19. We conclude that patients being treated with ACEIs and ARBs should continue their use for approved indications. |Angiotensin Receptor Antagonists/administration & dosage/*adverse effects/pharmacology[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Angiotensin-Converting Enzyme Inhibitors/administration & dosage/*adverse effects/pharmacology[MESH] |Animals[MESH] |COVID-19[MESH] |Coronavirus Infections/drug therapy/*etiology[MESH] |Dose-Response Relationship, Drug[MESH] |Humans[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/blood/*metabolism/urine[MESH]Risks of ACE Inhibitor and ARB Usage in COVID-19: Evaluating the Evide(epmc).pdf DeepDyve Pubget Overpricing