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10.1002/jmv.25920 http://scihub22266oqcxt.onion/10.1002/jmv.25920 32320059!7264677!32320059     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2020 ; 92 (9): 1469-1474 Nephropedia Template TP {{tp|p=32320059|t=2020. Potential of live pathogen vaccines for defeating the COVID-19 pandemic: History and mechanism |pdf=|usr=}}{{32320059}} gab.com Text Potential of live pathogen vaccines for defeating the COVID-19 pandemic: History and mechanism JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32320059 #FOAvip The whole world has entered a terrible crisis with a huge and increasing number of human deaths and economic losses in fighting the pandemic of COVID-19 caused by the novel coronavirus termed SARS-CoV-2. The live pathogen vaccine (LPV) strategy, which originated in ancient China for fighting smallpox, has been applied successfully by US military recruits for decades to control acute respiratory diseases caused by types 4 and 7 adenoviruses. This strategy has also been widely employed in veterinary medicine. These facts suggest a fast way out of the current pandemic crisis, namely that SARS-CoV-2 could be directly used as a live vaccine. Beyond the two traditional mechanisms to guarantee the LPV's safety (the LPV seed strain is properly selected; the LPV is inoculated bypassing the respiratory sites of pathology), three novel mechanisms to further ensure the LPV's safety are available (the virus replication is inhibited with early use of an antiviral drug; symptomatic LPV recipients are cured with convalescent plasma; the LPV is inoculated in the hot season). This LPV strategy has multiple potential advantages over other options and could reduce morbidity and mortality greatly as well as the economic loss caused by the pandemic. The safety and efficacy of this strategy should be investigated strictly using animal experiments and clinical trials, and even if the experiments and trials all support the strategy, it should be implemented with enough caution. Twit Text FOAVip Potential of live pathogen vaccines for defeating the COVID-19 pandemic: History and mechanism ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32320059 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32320059 #FOAvip English Wikipedia <ref>{{Cite pmid|32320059}}</ref> Potential of live pathogen vaccines for defeating the COVID-19 pandemic: History and mechanism #MMPMID32320059 Chen JW; Chen JM J Med Virol 2020[Sep]; 92 (9): 1469-1474 PMID32320059show ga The whole world has entered a terrible crisis with a huge and increasing number of human deaths and economic losses in fighting the pandemic of COVID-19 caused by the novel coronavirus termed SARS-CoV-2. The live pathogen vaccine (LPV) strategy, which originated in ancient China for fighting smallpox, has been applied successfully by US military recruits for decades to control acute respiratory diseases caused by types 4 and 7 adenoviruses. This strategy has also been widely employed in veterinary medicine. These facts suggest a fast way out of the current pandemic crisis, namely that SARS-CoV-2 could be directly used as a live vaccine. Beyond the two traditional mechanisms to guarantee the LPV's safety (the LPV seed strain is properly selected; the LPV is inoculated bypassing the respiratory sites of pathology), three novel mechanisms to further ensure the LPV's safety are available (the virus replication is inhibited with early use of an antiviral drug; symptomatic LPV recipients are cured with convalescent plasma; the LPV is inoculated in the hot season). This LPV strategy has multiple potential advantages over other options and could reduce morbidity and mortality greatly as well as the economic loss caused by the pandemic. The safety and efficacy of this strategy should be investigated strictly using animal experiments and clinical trials, and even if the experiments and trials all support the strategy, it should be implemented with enough caution. |Animals[MESH] |COVID-19 Vaccines/*therapeutic use[MESH] |COVID-19/*prevention & control[MESH] |Clinical Trials as Topic[MESH] |Humans[MESH] |Pandemics[MESH] |Safety[MESH]Potential of live pathogen vaccines for defeating the COVID-19 pandemi(epmc).pdf DeepDyve Pubget Overpricing