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10.3390/molecules25081834 http://scihub22266oqcxt.onion/10.3390/molecules25081834 32316270!7221598!32316270     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Molecules 2020 ; 25 (8): ä Nephropedia Template TP {{tp|p=32316270|t=2020. COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help |pdf=|usr=}}{{32316270}} gab.com Text COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help JO: Molecules http://www.kidney.de/pget.php?&tw=1&pmid=32316270 #FOAvip The desperate need to find drugs for COVID-19 has indicated repurposing strategies as our quickest way to obtain efficacious medicines. One of the options under investigation is the old antimalarial drug, chloroquine, and its analog, hydroxychloroquine. Developed as synthetic succedanea of cinchona alkaloids, these chiral antimalarials are currently in use as the racemate. Besides the ethical concern related to accelerated large-scale clinical trials of drugs with unproven efficacy, the known potential detrimental cardiac effects of these drugs should also be considered. In principle, the safety profile might be ameliorated by using chloroquine/hydroxychloroquine single enantiomers in place of the racemate. Twit Text FOAVip COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help ????Molecules http://www.kidney.de/pget.php?&tw=1&pmid=32316270 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32316270 #FOAvip English Wikipedia <ref>{{Cite pmid|32316270}}</ref> COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help #MMPMID32316270 Lentini G; Cavalluzzi MM; Habtemariam S Molecules 2020[Apr]; 25 (8): ä PMID32316270show ga The desperate need to find drugs for COVID-19 has indicated repurposing strategies as our quickest way to obtain efficacious medicines. One of the options under investigation is the old antimalarial drug, chloroquine, and its analog, hydroxychloroquine. Developed as synthetic succedanea of cinchona alkaloids, these chiral antimalarials are currently in use as the racemate. Besides the ethical concern related to accelerated large-scale clinical trials of drugs with unproven efficacy, the known potential detrimental cardiac effects of these drugs should also be considered. In principle, the safety profile might be ameliorated by using chloroquine/hydroxychloroquine single enantiomers in place of the racemate. |*Betacoronavirus[MESH] |*Drug Repositioning[MESH] |Antimalarials[MESH] |Antiviral Agents/adverse effects/chemistry/pharmacology/therapeutic use[MESH] |Arrhythmias, Cardiac/chemically induced[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Cardiotoxicity[MESH] |Chloroquine/*adverse effects/chemistry/pharmacology/*therapeutic use[MESH] |Coronavirus Infections/*drug therapy[MESH] |Humans[MESH] |Hydroxychloroquine/adverse effects/chemistry/therapeutic use[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy[MESH] |SARS-CoV-2[MESH]COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirali(epmc).pdf DeepDyve Pubget Overpricing