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  • COVID-19-Related Severe Hypercoagulability in Patients Admitted to Intensive Care Unit for Acute Respiratory Failure #MMPMID32316063
  • Spiezia L; Boscolo A; Poletto F; Cerruti L; Tiberio I; Campello E; Navalesi P; Simioni P
  • Thromb Haemost 2020[Jun]; 120 (6): 998-1000 PMID32316063show ga
  • In late December 2019 an outbreak of a novel coronavirus (SARS-CoV-2) causing severe pneumonia (COVID-19) was reported in Wuhan, Hubei Province, China. A common finding in most COVID-19 patients is high D-dimer levels which are associated with a worse prognosis. We aimed to evaluate coagulation abnormalities via traditional tests and whole blood thromboelastometry profiles in a group of 22 (mean age 67 +/- 8 years, M:F 20:2) consecutive patients admitted to the Intensive Care Unit of Padova University Hospital for acute respiratory failure due to COVID-19. Cases showed significantly higher fibrinogen and D-dimer plasma levels versus healthy controls (p < 0.0001 in both comparisons). Interestingly enough, markedly hypercoagulable thromboelastometry profiles were observed in COVID-19 patients, as reflected by shorter Clot Formation Time (CFT) in INTEM (p = 0.0002) and EXTEM (p = 0.01) and higher Maximum Clot Firmness (MCF) in INTEM, EXTEM and FIBTEM (p < 0.001 in all comparisons). In conclusion, COVID-19 patients with acute respiratory failure present a severe hypercoagulability rather than consumptive coagulopathy. Fibrin formation and polymerization may predispose to thrombosis and correlate with a worse outcome.
  • |*Blood Coagulation[MESH]
  • |Acute Disease[MESH]
  • |Aged[MESH]
  • |Area Under Curve[MESH]
  • |Betacoronavirus[MESH]
  • |Blood Coagulation Tests[MESH]
  • |Coronavirus Infections/*blood/complications/*therapy[MESH]
  • |Critical Care[MESH]
  • |Female[MESH]
  • |Fibrin Fibrinogen Degradation Products/analysis[MESH]
  • |Fibrin/analysis[MESH]
  • |Fibrinogen/analysis[MESH]
  • |Humans[MESH]
  • |Intensive Care Units[MESH]
  • |Italy/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*blood/complications/*therapy[MESH]
  • |Prognosis[MESH]
  • |Respiration Disorders/*complications/*therapy[MESH]
  • |Thrombelastography[MESH]
  • |Thrombophilia/*complications[MESH]
  • |Treatment Outcome[MESH]

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  • suck abstract from ncbi

    998 6.120 2020