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10.1111/cts.12805

http://scihub22266oqcxt.onion/10.1111/cts.12805
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32315487!7264560!32315487
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suck abstract from ncbi


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pmid32315487      Clin+Transl+Sci 2020 ; 13 (6): 1077-1086
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  • Clinical and Autoimmune Characteristics of Severe and Critical Cases of COVID-19 #MMPMID32315487
  • Zhou Y; Han T; Chen J; Hou C; Hua L; He S; Guo Y; Zhang S; Wang Y; Yuan J; Zhao C; Zhang J; Jia Q; Zuo X; Li J; Wang L; Cao Q; Jia E
  • Clin Transl Sci 2020[Nov]; 13 (6): 1077-1086 PMID32315487show ga
  • In this study we report on the clinical and autoimmune characteristics of severe and critical novel coronavirus pneumonia caused by severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2). The clinical, autoimmune, and laboratory characteristics of 21 patients who had laboratory-confirmed severe and critical cases of coronavirus disease 2019 (COVID-19) from the intensive care unit of the Huangshi Central Hospital, Hubei Province, China, were investigated. A total of 21 patients (13 men and 8 women), including 8 (38.1%) severe cases and 13 (61.9%) critical cases, were enrolled. Cough (90.5%) and fever (81.0%) were the dominant symptoms, and most patients (76.2%) had at least one coexisting disorder on admission. The most common characteristics on chest computed tomography were ground-glass opacity (100%) and bilateral patchy shadowing (76.2%). The most common findings on laboratory measurement were lymphocytopenia (85.7%) and elevated levels of C-reactive protein (94.7%) and interleukin-6 (89.5%). The prevalence of anti-52 kDa SSA/Ro antibody, anti-60 kDa SSA/Ro antibody, and antinuclear antibody was 20%, 25%, and 50%, respectively. We also retrospectively analyzed the clinical and laboratory data from 21 severe and critical cases of COVID-19. Autoimmune phenomena exist in COVID-19 subjects, and the present results provide the rationale for a strategy of preventing immune dysfunction and optimal immunosuppressive therapy.
  • |*Autoimmunity[MESH]
  • |*SARS-CoV-2[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Autoantibodies/blood[MESH]
  • |COVID-19/diagnostic imaging/*immunology/mortality[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]


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