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  • Understanding evolution of SARS-CoV-2: A perspective from analysis of genetic diversity of RdRp gene #MMPMID32314811
  • Kasibhatla SM; Kinikar M; Limaye S; Kale MM; Kulkarni-Kale U
  • J Med Virol 2020[Oct]; 92 (10): 1932-1937 PMID32314811show ga
  • Coronavirus disease 2019 emerged as the first example of "Disease X", a hypothetical disease of humans caused by an unknown infectious agent that was named as novel coronavirus and subsequently designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The origin of the outbreak at the animal market in Wuhan, China implies it as a case of zoonotic spillover. The study was designed to understand evolution of Betacoronaviruses and in particular diversification of SARS-CoV-2 using RNA dependent RNA polymerase (RdRp) gene, a stable genetic marker. Phylogenetic and population stratification analyses were carried out using maximum likelihood and Bayesian methods, respectively. Molecular phylogeny using RdRp showed that SARS-CoV-2 isolates cluster together. Bat-CoV isolate RaTG13 and Pangolin-CoVs are observed to branch off prior to SARS-CoV-2 cluster. While SARS-CoV form a single cluster, Bat-CoVs form multiple clusters. Population-based analyses revealed that both SARS-CoV-2 and SARS-CoV form separate clusters with no admixture. Bat-CoVs were found to have single and mixed ancestry and clustered as four sub-populations. Population-based analyses of Betacoronaviruses using RdRp revealed that SARS-CoV-2 is a homogeneous population. SARS-CoV-2 appears to have evolved from Bat-CoV isolate RaTG13, which diversified from a common ancestor from which Pangolin-CoVs have also evolved. The admixed Bat-CoV sub-populations indicate that bats serve as reservoirs harboring virus ensembles that are responsible for zoonotic spillovers such as SARS-CoV and SARS-CoV-2. The extent of admixed isolates of Bat-CoVs observed in population diversification studies underline the need for periodic surveillance of bats and other animal reservoirs for potential spillovers as a measure towards preparedness for emergence of zoonosis.
  • |*Evolution, Molecular[MESH]
  • |Animals[MESH]
  • |Bayes Theorem[MESH]
  • |Chiroptera/virology[MESH]
  • |Coronavirus RNA-Dependent RNA Polymerase/*genetics[MESH]
  • |Genetics, Population[MESH]
  • |Humans[MESH]
  • |Likelihood Functions[MESH]
  • |Pangolins/virology[MESH]
  • |Phylogeny[MESH]
  • |SARS-CoV-2/*genetics[MESH]
  • |Zoonoses/virology[MESH]

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  • suck abstract from ncbi

    1932 10.92 2020