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suck abstract from ncbi


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pmid32314329      Lakartidningen 2020 ; 117 (ä): ä
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  • ACE-2 och coronavirus - en fraga om balans och dynamik? #MMPMID32314329
  • Lundstrom A; Sanden P
  • Lakartidningen 2020[Apr]; 117 (ä): ä PMID32314329show ga
  • The new SARS-CoV-2 virus enters cells via angiotensin-converting enzyme 2 (ACE2). ACE2 counteracts ACE and angiotensin II in the renin-angiotensin-aldosterone system (RAAS) and has critical functions in the lung and cardiovascular system. SARS-CoV was found to down-regulate ACE2, leaving angiotensin II unbalanced in affected organs. A similar effect of SARS-CoV-2 could partly explain risk factors and symptoms, and could potentially be treatable.
  • |*Coronavirus[MESH]
  • |*Peptidyl-Dipeptidase A/physiology[MESH]
  • |*Renin-Angiotensin System/physiology[MESH]
  • |Angiotensin II/physiology[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Betacoronavirus/*pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*virology[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*virology[MESH]
  • |Risk Factors[MESH]


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