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10.1002/adtp.201800143 http://scihub22266oqcxt.onion/10.1002/adtp.201800143 32313833!7161847!32313833     free     free     free       Adv+Ther+(Weinh) 2019 ; 2 (7): 1800143 Nephropedia Template TP {{tp|p=32313833|t=2019. PDZ Domains as Drug Targets |pdf=|usr=}}{{32313833}} gab.com Text PDZ Domains as Drug Targets JO: Adv Ther (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=32313833 #FOAvip Protein-protein interactions within protein networks shape the human interactome, which often is promoted by specialized protein interaction modules, such as the postsynaptic density-95 (PSD-95), discs-large, zona occludens 1 (ZO-1) (PDZ) domains. PDZ domains play a role in several cellular functions, from cell-cell communication and polarization, to regulation of protein transport and protein metabolism. PDZ domain proteins are also crucial in the formation and stability of protein complexes, establishing an important bridge between extracellular stimuli detected by transmembrane receptors and intracellular responses. PDZ domains have been suggested as promising drug targets in several diseases, ranging from neurological and oncological disorders to viral infections. In this review, the authors describe structural and genetic aspects of PDZ-containing proteins and discuss the current status of the development of small-molecule and peptide modulators of PDZ domains. An overview of potential new therapeutic interventions in PDZ-mediated protein networks is also provided. Twit Text FOAVip PDZ Domains as Drug Targets ????Adv Ther (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=32313833 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32313833 #FOAvip English Wikipedia <ref>{{Cite pmid|32313833}}</ref> PDZ Domains as Drug Targets #MMPMID32313833 Christensen NR; Calyseva J; Fernandes EFA; Luchow S; Clemmensen LS; Haugaard-Kedstrom LM; Stromgaard K Adv Ther (Weinh) 2019[Jul]; 2 (7): 1800143 PMID32313833show ga Protein-protein interactions within protein networks shape the human interactome, which often is promoted by specialized protein interaction modules, such as the postsynaptic density-95 (PSD-95), discs-large, zona occludens 1 (ZO-1) (PDZ) domains. PDZ domains play a role in several cellular functions, from cell-cell communication and polarization, to regulation of protein transport and protein metabolism. PDZ domain proteins are also crucial in the formation and stability of protein complexes, establishing an important bridge between extracellular stimuli detected by transmembrane receptors and intracellular responses. PDZ domains have been suggested as promising drug targets in several diseases, ranging from neurological and oncological disorders to viral infections. In this review, the authors describe structural and genetic aspects of PDZ-containing proteins and discuss the current status of the development of small-molecule and peptide modulators of PDZ domains. An overview of potential new therapeutic interventions in PDZ-mediated protein networks is also provided. äPDZ Domains as Drug Targets (epmc).pdf DeepDyve Pubget Overpricing