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10.7499/j.issn.1008-8830.2003199

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32312364!7389687!32312364
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suck abstract from ncbi


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pmid32312364      Zhongguo+Dang+Dai+Er+Ke+Za+Zhi 2020 ; 22 (4): 294-298
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  • Clinical features of children with SARS-CoV-2 infection: an analysis of 13 cases from Changsha, China #MMPMID32312364
  • Tan X; Huang J; Zhao F; Zhou Y; Li JQ; Wang XY
  • Zhongguo Dang Dai Er Ke Za Zhi 2020[Apr]; 22 (4): 294-298 PMID32312364show ga
  • OBJECTIVE: To study the clinical features of children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. METHODS: A retrospective analysis was performed for the clinical data of 13 children with SARS-CoV-2 infection who hospitalized in a Changsha hospital. RESULTS: All 13 children had the disease onset due to family aggregation. Of the 13 children, 2 had no symptoms, and the other 11 children had the clinical manifestations of fever, cough, pharyngeal discomfort, abdominal pain, diarrhea, convulsions, or vomiting. As for clinical typing, 7 had mild type, 5 had common type, and 1 had severe type. The median duration of fever was 2 days in 6 children. All 13 children had normal levels of peripheral blood lymphocyte counts, immunoglobulins, CD4, CD8, and interleukin-6. The median time to clearance of SARS-CoV-2 was 13 days in the nasopharyngeal swabs of the 13 children. Three children presented false negatives for RT-PCR of SARS-CoV-2. SARS-CoV-2 RNA remained detectable in stools for 12 days after the nasopharyngeal swab test yielded a negative result. Abnormal CT findings were observed in 6 children. All 13 children were cured and discharged and they were normal at 2 weeks after discharge. CONCLUSIONS: Intra-family contact is the main transmission route of SARS-CoV-2 infection in children, and there is also a possibility of fecal-oral transmission. Mild and common types are the major clinical types in children with SARS-CoV-2 infection, and cytokine storm is not observed. Children with SARS-CoV-2 infection tend to have a good short-term prognosis, and follow-up is needed to observe their long-term prognosis. Multiple nucleic acid tests should be performed for patients with SARS-CoV-2 infection and their close contacts by multiple site sampling.
  • |*Betacoronavirus/pathogenicity[MESH]
  • |*Coronavirus Infections/complications/diagnosis/immunology/transmission[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/complications/diagnosis/immunology/transmission[MESH]
  • |Abdominal Pain/etiology[MESH]
  • |Asymptomatic Diseases[MESH]
  • |Biomarkers/analysis[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Child[MESH]
  • |China[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Cough/etiology[MESH]
  • |Diarrhea/etiology[MESH]
  • |Feces/virology[MESH]
  • |Fever/etiology[MESH]
  • |Humans[MESH]
  • |Lymphocyte Count[MESH]
  • |RNA, Viral/analysis[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Seizures/etiology[MESH]


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