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10.1016/j.jacc.2020.04.031

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32311448!7164881!32311448
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suck abstract from ncbi


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pmid32311448      J+Am+Coll+Cardiol 2020 ; 75 (23): 2950-2973
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  • COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up: JACC State-of-the-Art Review #MMPMID32311448
  • Bikdeli B; Madhavan MV; Jimenez D; Chuich T; Dreyfus I; Driggin E; Nigoghossian C; Ageno W; Madjid M; Guo Y; Tang LV; Hu Y; Giri J; Cushman M; Quere I; Dimakakos EP; Gibson CM; Lippi G; Favaloro EJ; Fareed J; Caprini JA; Tafur AJ; Burton JR; Francese DP; Wang EY; Falanga A; McLintock C; Hunt BJ; Spyropoulos AC; Barnes GD; Eikelboom JW; Weinberg I; Schulman S; Carrier M; Piazza G; Beckman JA; Steg PG; Stone GW; Rosenkranz S; Goldhaber SZ; Parikh SA; Monreal M; Krumholz HM; Konstantinides SV; Weitz JI; Lip GYH
  • J Am Coll Cardiol 2020[Jun]; 75 (23): 2950-2973 PMID32311448show ga
  • Coronavirus disease-2019 (COVID-19), a viral respiratory illness caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), may predispose patients to thrombotic disease, both in the venous and arterial circulations, because of excessive inflammation, platelet activation, endothelial dysfunction, and stasis. In addition, many patients receiving antithrombotic therapy for thrombotic disease may develop COVID-19, which can have implications for choice, dosing, and laboratory monitoring of antithrombotic therapy. Moreover, during a time with much focus on COVID-19, it is critical to consider how to optimize the available technology to care for patients without COVID-19 who have thrombotic disease. Herein, the authors review the current understanding of the pathogenesis, epidemiology, management, and outcomes of patients with COVID-19 who develop venous or arterial thrombosis, of those with pre-existing thrombotic disease who develop COVID-19, or those who need prevention or care for their thrombotic disease during the COVID-19 pandemic.
  • |*Coronavirus Infections/blood/complications/epidemiology/therapy[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/blood/complications/epidemiology/therapy[MESH]
  • |*Thromboembolism/drug therapy/epidemiology/etiology/physiopathology[MESH]
  • |Anticoagulants/*pharmacology[MESH]
  • |Betacoronavirus/*isolation & purification[MESH]
  • |COVID-19[MESH]
  • |Fibrinolytic Agents/*pharmacology[MESH]
  • |Humans[MESH]
  • |Platelet Aggregation Inhibitors/*pharmacology[MESH]
  • |SARS-CoV-2[MESH]


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