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10.1080/07391102.2020.1758789 http://scihub22266oqcxt.onion/10.1080/07391102.2020.1758789 32306854!7189410!32306854     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biomol+Struct+Dyn 2021 ; 39 (8): 2923-2931 Nephropedia Template TP {{tp|p=32306854|t=2021. Novel guanosine derivatives against MERS CoV polymerase: An in silico perspective |pdf=|usr=}}{{32306854}} gab.com Text Novel guanosine derivatives against MERS CoV polymerase: An in silico perspective JO: J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=32306854 #FOAvip The Middle East Respiratory Syndrome Coronavirus (MERS CoV), also termed camel flu, is a new viral infection that first reported in the year 2012 in the Middle East region and further spread during the last seven years. MERS CoV is characterized by its high mortality rate among different human coronaviruses. MERS CoV polymerase shares more than 20% sequence identity with the Hepatitis C Virus (HCV) Non-structural 5b (NS5b) RNA dependent RNA polymerase (RdRp). Despite the low sequence identity, the active site is conserved between the two proteins, with two consecutive aspartates that are crucial in the nucleotide transfer reaction. In this study, seven nucleotide inhibitors have been tested against MERS CoV RdRp using molecular modeling and docking simulations, from which four are novel compounds. Molecular Dynamics Simulation for 260 nanoseconds is performed on the MERS CoV RdRp model to test the effect of protein dynamics on the binding affinities to the tested nucleotide inhibitors. Results support the hypothesis of using the anti-polymerases (Anti-HCV drugs) against MERS CoV RdRp as a potent candidates. Besides four novel compounds are suggested as a seed for high performance inhibitors against MERS CoV RdRp.Communicated by Ramaswamy H. Sarma. Twit Text FOAVip Novel guanosine derivatives against MERS CoV polymerase: An in silico perspective ????J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=32306854 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32306854 #FOAvip English Wikipedia <ref>{{Cite pmid|32306854}}</ref> Novel guanosine derivatives against MERS CoV polymerase: An in silico perspective #MMPMID32306854 Elfiky AA; Azzam EB J Biomol Struct Dyn 2021[May]; 39 (8): 2923-2931 PMID32306854show ga The Middle East Respiratory Syndrome Coronavirus (MERS CoV), also termed camel flu, is a new viral infection that first reported in the year 2012 in the Middle East region and further spread during the last seven years. MERS CoV is characterized by its high mortality rate among different human coronaviruses. MERS CoV polymerase shares more than 20% sequence identity with the Hepatitis C Virus (HCV) Non-structural 5b (NS5b) RNA dependent RNA polymerase (RdRp). Despite the low sequence identity, the active site is conserved between the two proteins, with two consecutive aspartates that are crucial in the nucleotide transfer reaction. In this study, seven nucleotide inhibitors have been tested against MERS CoV RdRp using molecular modeling and docking simulations, from which four are novel compounds. Molecular Dynamics Simulation for 260 nanoseconds is performed on the MERS CoV RdRp model to test the effect of protein dynamics on the binding affinities to the tested nucleotide inhibitors. Results support the hypothesis of using the anti-polymerases (Anti-HCV drugs) against MERS CoV RdRp as a potent candidates. Besides four novel compounds are suggested as a seed for high performance inhibitors against MERS CoV RdRp.Communicated by Ramaswamy H. Sarma. |*Middle East Respiratory Syndrome Coronavirus[MESH] |Antiviral Agents/pharmacology[MESH] |Computer Simulation[MESH] |Guanosine[MESH]Novel guanosine derivatives against MERS CoV polymerase: An in silico (epmc).pdf DeepDyve Pubget Overpricing