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10.3760/cma.j.cn501113-20200224-00067

http://scihub22266oqcxt.onion/10.3760/cma.j.cn501113-20200224-00067
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32306657!ä!32306657

suck abstract from ncbi


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pmid32306657      Zhonghua+Gan+Zang+Bing+Za+Zhi 2020 ; 28 (3): 240-246
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  • Clinical features and outcome of treatment for novel coronavirus pneumonia: a meta-analysis #MMPMID32306657
  • Wu YY; Li HY; Xu XB; Zheng KX; Qi XS; Guo XZ
  • Zhonghua Gan Zang Bing Za Zhi 2020[Mar]; 28 (3): 240-246 PMID32306657show ga
  • Objective: To investigate the clinical features and outcome of treatment for novel coronavirus pneumonia. Methods: Literature on novel coronavirus pneumonia was retrieved from PubMed and EMBASE databases. The relevant data was extracted and a meta-analysis was performed using StatsDirect statistical software V.2.8.0 to calculate the combined odds ratio. Results: Seven studies were included, consisting of 1594 cases. The meta-analysis result showed that the most common clinical symptoms of the novel coronavirus pneumonia were fever (91.6%) and cough (64.5%), followed by dyspnea (32.8%) and sputum (28.1%). Headache (10.5%), sore throat (11.2%), hemoptysis (3.2%), diarrhea (6.6%) and the other symptoms were relatively rare. Aspartate aminotransferase (29%), alanine transaminase (22.7%), and total bilirubin (11.7%) levels were elevated, except for serum albumin levels (80.4%). The common therapeutic agents used were antibiotics (87.7%), antiviral drugs (75.5%), and glucocorticoids (26.6%), while antifungal agents (7.7%) were used in few. Mechanical ventilation (13.4%), extracorporeal membrane oxygenation (1.9%), and continuous renal replacement therapy (3.8%) were used in severe cases. The rate of mortality in hospital was 7.7%, respectively. Heterogeneity between studies was significant; however, subgroup and sensitivity analysis had failed to identify clear sources of heterogeneity. Conclusion: Fever, cough and liver dysfunction are the main clinical manifestations of this disease and the mortality rate is low.
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*diagnosis/pathology/*therapy[MESH]
  • |Cough/virology[MESH]
  • |Fever/virology[MESH]
  • |Humans[MESH]
  • |Liver/physiopathology/virology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis/pathology/*therapy[MESH]
  • |SARS-CoV-2[MESH]


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