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10.1016/j.micinf.2020.04.004 http://scihub22266oqcxt.onion/10.1016/j.micinf.2020.04.004 32305500!7162740!32305500     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microbes+Infect 2020 ; 22 (4-5): 154-156 Nephropedia Template TP {{tp|p=32305500|t=2020. Chloroquine paradox may cause more damage than help fight COVID-19 |pdf=|usr=}}{{32305500}} gab.com Text Chloroquine paradox may cause more damage than help fight COVID-19 JO: Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=32305500 #FOAvip Novel coronavirus disease 2019 (COVID-19) pandemic is the most recent health care crisis without specific prophylactic or therapeutic drugs. Antimalarial drug chloroquine (CHL) and its safer derivative hydroxychloroquine (HCHL) have been proposed to be repurposed to treat SARS coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19. CHL/HCHL have anti-inflammatory activity and are used to treat rheumatoid arthritis, osteoarthritis and lupus. Although, CHL/HCHL have an anti-viral activity against several viruses in cell-cultures, the anti-viral activity in-vivo is questionable. Repurposing of CHL/HCHL to treat SARS-CoV-2 infection is appealing. However, there is empirical evidence from animal studies with other viruses suggesting that CHL/HCHL may have an untoward paradoxical effect. One thus cannot exclude the possibility that CHL may increase the severity of the disease and prove deleterious both for the patients and public health efforts to contain the highly contagious and explosive spread of SARS-CoV-2. Twit Text FOAVip Chloroquine paradox may cause more damage than help fight COVID-19 ????Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=32305500 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32305500 #FOAvip English Wikipedia <ref>{{Cite pmid|32305500}}</ref> Chloroquine paradox may cause more damage than help fight COVID-19 #MMPMID32305500 Sharma A Microbes Infect 2020[May]; 22 (4-5): 154-156 PMID32305500show ga Novel coronavirus disease 2019 (COVID-19) pandemic is the most recent health care crisis without specific prophylactic or therapeutic drugs. Antimalarial drug chloroquine (CHL) and its safer derivative hydroxychloroquine (HCHL) have been proposed to be repurposed to treat SARS coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19. CHL/HCHL have anti-inflammatory activity and are used to treat rheumatoid arthritis, osteoarthritis and lupus. Although, CHL/HCHL have an anti-viral activity against several viruses in cell-cultures, the anti-viral activity in-vivo is questionable. Repurposing of CHL/HCHL to treat SARS-CoV-2 infection is appealing. However, there is empirical evidence from animal studies with other viruses suggesting that CHL/HCHL may have an untoward paradoxical effect. One thus cannot exclude the possibility that CHL may increase the severity of the disease and prove deleterious both for the patients and public health efforts to contain the highly contagious and explosive spread of SARS-CoV-2. |*Betacoronavirus[MESH] |Antimalarials/*adverse effects/*therapeutic use[MESH] |COVID-19[MESH] |Chloroquine/*adverse effects/*therapeutic use[MESH] |Coronavirus Infections/*drug therapy[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy[MESH]Chloroquine paradox may cause more damage than help fight COVID-19 (epmc).pdf DeepDyve Pubget Overpricing