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10.1016/j.bcp.2020.113982 http://scihub22266oqcxt.onion/10.1016/j.bcp.2020.113982 32305436!7162792!32305436     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Pharmacol 2020 ; 177 (ä): 113982 Nephropedia Template TP {{tp|p=32305436|t=2020. The seafood Musculus senhousei shows anti-influenza A virus activity by targeting virion envelope lipids |pdf=|usr=}}{{32305436}} gab.com Text The seafood Musculus senhousei shows anti-influenza A virus activity by targeting virion envelope lipids JO: Biochem Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32305436 #FOAvip Marine environments are known to be a new source of structurally diverse bioactive molecules. In this paper, we identified a porphyrin derivative of Pyropheophorbide a (PPa) from the mussel Musculus senhousei (M. senhousei) that showed broad anti-influenza A virus activity in vitro against a panel of influenza A viral strains. The analysis of the mechanism of action indicated that PPa functions in the early stage of virus infection by interacting with the lipid bilayer of the virion, resulting in an alteration of membrane-associated functions, thereby blocking the entry of enveloped viruses into host cells. In addition, the anti-influenza A virus activity of PPa was further assessed in mice infected with the influenza A virus. The survival rate and mean survival time of mice were apparently prolonged compared with the control group which was not treated with the drug. Therefore, PPa and its derivatives may represent lead compounds for controlling influenza A virus infection. Twit Text FOAVip The seafood Musculus senhousei shows anti-influenza A virus activity by targeting virion envelope lipids ????Biochem Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32305436 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32305436 #FOAvip English Wikipedia <ref>{{Cite pmid|32305436}}</ref> The seafood Musculus senhousei shows anti-influenza A virus activity by targeting virion envelope lipids #MMPMID32305436 Chen D; Lu S; Yang G; Pan X; Fan S; Xie X; Chen Q; Li F; Li Z; Wu S; He J Biochem Pharmacol 2020[Jul]; 177 (ä): 113982 PMID32305436show ga Marine environments are known to be a new source of structurally diverse bioactive molecules. In this paper, we identified a porphyrin derivative of Pyropheophorbide a (PPa) from the mussel Musculus senhousei (M. senhousei) that showed broad anti-influenza A virus activity in vitro against a panel of influenza A viral strains. The analysis of the mechanism of action indicated that PPa functions in the early stage of virus infection by interacting with the lipid bilayer of the virion, resulting in an alteration of membrane-associated functions, thereby blocking the entry of enveloped viruses into host cells. In addition, the anti-influenza A virus activity of PPa was further assessed in mice infected with the influenza A virus. The survival rate and mean survival time of mice were apparently prolonged compared with the control group which was not treated with the drug. Therefore, PPa and its derivatives may represent lead compounds for controlling influenza A virus infection. |Animals[MESH] |Antiviral Agents/chemistry/isolation & purification/*pharmacology[MESH] |Betacoronavirus/*drug effects/growth & development/metabolism[MESH] |Bivalvia/*chemistry[MESH] |Chlorophyll/*analogs & derivatives/chemistry/isolation & purification/pharmacology[MESH] |Dogs[MESH] |Host-Pathogen Interactions/drug effects[MESH] |Influenza A Virus, H1N1 Subtype/*drug effects/growth & development/metabolism[MESH] |Lipid Bilayers/antagonists & inhibitors/chemistry/metabolism[MESH] |Madin Darby Canine Kidney Cells[MESH] |Male[MESH] |Mice[MESH] |Orthomyxoviridae Infections/drug therapy/mortality/pathology/virology[MESH] |Respiratory Syncytial Viruses/*drug effects/growth & development/metabolism[MESH] |SARS-CoV-2[MESH] |Seafood[MESH] |Survival Analysis[MESH] |Virion/*drug effects/growth & development/metabolism[MESH]The seafood Musculus senhousei shows anti-influenza A virus activity b(epmc).pdf DeepDyve Pubget Overpricing