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10.1055/s-0040-1710050

http://scihub22266oqcxt.onion/10.1055/s-0040-1710050
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32305046!7356080!32305046
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suck abstract from ncbi


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pmid32305046      Am+J+Perinatol 2020 ; 37 (8): 861-865
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  • Severe COVID-19 during Pregnancy and Possible Vertical Transmission #MMPMID32305046
  • Alzamora MC; Paredes T; Caceres D; Webb CM; Valdez LM; La Rosa M
  • Am J Perinatol 2020[Jun]; 37 (8): 861-865 PMID32305046show ga
  • There are few cases of pregnant women with novel corona virus 2019 (COVID-19) in the literature, most of them with a mild illness course. There is limited evidence about in utero infection and early positive neonatal testing. A 41-year-old G3P2 with a history of previous cesarean deliveries and diabetes mellitus presented with a 4-day history of malaise, low-grade fever, and progressive shortness of breath. A nasopharyngeal swab was positive for COVID-19, COVID-19 serology was negative. The patient developed respiratory failure requiring mechanical ventilation on day 5 of disease onset. The patient underwent a cesarean delivery, and neonatal isolation was implemented immediately after birth, without delayed cord clamping or skin-to-skin contact. The neonatal nasopharyngeal swab, 16 hours after delivery, was positive for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) real-time polymerase chain reaction (RT-PCR), and immunoglobulin (Ig)-M and IgG for SARS-CoV-2 were negative. Maternal IgM and IgG were positive on postpartum day 4 (day 9 after symptom onset). We report a severe presentation of COVID-19 during pregnancy. To our knowledge, this is the earliest reported positive PCR in the neonate, raising the concern for vertical transmission. We suggest pregnant women should be considered as a high-risk group and minimize exposures for these reasons. KEY POINTS: . We report a severe presentation of COVID-19 in pregnancy requiring invasive ventilatory support.. . This is a case of positive RT-PCR in first day of life, suggesting possible vertical transmission.. . There were no detectable maternal antibodies for COVID-19 until after delivery..
  • |*Betacoronavirus/isolation & purification/pathogenicity[MESH]
  • |*Coronavirus Infections/diagnosis/physiopathology/therapy/transmission[MESH]
  • |*Infant, Newborn, Diseases/physiopathology/therapy/virology[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/diagnosis/physiopathology/therapy/transmission[MESH]
  • |*Pregnancy Complications, Infectious/physiopathology/therapy/virology[MESH]
  • |*Respiratory Insufficiency/etiology/physiopathology/therapy[MESH]
  • |Adult[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Cesarean Section/*methods[MESH]
  • |Clinical Laboratory Techniques/methods[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant, Newborn[MESH]
  • |Infectious Disease Transmission, Vertical[MESH]
  • |Pregnancy[MESH]
  • |Pregnancy Outcome[MESH]
  • |Respiration, Artificial/*methods[MESH]
  • |SARS-CoV-2[MESH]


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