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10.1016/j.intimp.2020.106504

http://scihub22266oqcxt.onion/10.1016/j.intimp.2020.106504
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suck abstract from ncbi


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pmid32304994      Int+Immunopharmacol 2020 ; 84 (ä): 106504
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  • The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients #MMPMID32304994
  • Yang AP; Liu JP; Tao WQ; Li HM
  • Int Immunopharmacol 2020[Jul]; 84 (ä): 106504 PMID32304994show ga
  • AIM: To accumulate evidence that indicated the key role played by virus-triggered inflammation in the 2019-novel coronavirus disease (COVID-19) which emerged in Wuhan City and rapidly spread throughout China. METHODS: Age, neutrophil(NEU)-to-lymphocyte (LYM) ratio (NLR), lymphocyte-to-monocyte (MON) ratio, platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP) of 93 patients with laboratory confirmed COVID-19 were investigated and compared. The receiver operating characteristic curve was applied to determine the thresholds for five bio-markers, and their prognostic values were assessed via the Kaplan-Meier curve and multivariate COX regression models. RESULTS: The median age was 46.4 years old, and 37cases were females. A total of 27.8% of patients had been to Wuhan, and 73.1% had contacted with people from Wuhan. Fever (83.8%) and cough (70.9%) were the two most common symptoms. Elevated NLR and age were significantly associated with illness severity. The binary logistic analysis identified elevated NLR (hazard risk [HR] 2.46, 95% confidence interval [CI] 1.98-4.57) and age (HR 2.52, 95% CI 1.65-4.83) as independent factors for poor clinical outcome of COVID-19. NLR exhibited the largest area under the curve at 0.841, with the highest specificity (63.6%) and sensitivity (88%). CONCLUSIONS: Elevated age and NLR can be considered independent biomarkers for indicating poor clinical outcomes.
  • |*Betacoronavirus[MESH]
  • |Adult[MESH]
  • |Blood Platelets/*physiology[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/blood/*diagnosis/epidemiology/pathology[MESH]
  • |Epidemics[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lymphocyte Count[MESH]
  • |Lymphocytes/*physiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Monocytes/*physiology[MESH]
  • |Neutrophils/*physiology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/blood/*diagnosis/epidemiology/pathology[MESH]
  • |Prognosis[MESH]
  • |ROC Curve[MESH]


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