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10.1016/j.cmi.2020.04.012

http://scihub22266oqcxt.onion/10.1016/j.cmi.2020.04.012
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32304745!7159868!32304745
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suck abstract from ncbi

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  • Risk factors for disease severity, unimprovement, and mortality in COVID-19 patients in Wuhan, China #MMPMID32304745
  • Zhang J; Wang X; Jia X; Li J; Hu K; Chen G; Wei J; Gong Z; Zhou C; Yu H; Yu M; Lei H; Cheng F; Zhang B; Xu Y; Wang G; Dong W
  • Clin Microbiol Infect 2020[Jun]; 26 (6): 767-772 PMID32304745show ga
  • OBJECTIVE: In December 2019, coronavirus disease (COVID-19) emerged in Wuhan. However, the characteristics and risk factors associated with disease severity, unimprovement and mortality are unclear and our objective is to throw some light on these. METHODS: All consecutive patients diagnosed with COVID-19 admitted to the Renmin Hospital of Wuhan University from January 11 to February 6, 2020, were enrolled in this retrospective cohort study. RESULTS: A total of 663 COVID-19 patients were included in this study. Among these, 247 (37.3%) had at least one kind of chronic disease; 0.5% of the patients (n = 3) were diagnosed with mild COVID-19, while 37.8% (251/663), 47.5% (315/663), and 14.2% (94/663) were in moderate, severe, and critical conditions, respectively. In our hospital, during follow-up 251 of 663 patients (37.9%) improved and 25 patients died, a mortality rate of 3.77%. Older patients (>60 years old) and those with chronic diseases were prone to have a severe to critical COVID-19 condition, to show unimprovement, and to die (p <0.001, <0.001). Multivariate logistic regression analysis identified being male (OR = 0.486, 95%CI 0.311-0.758; p 0.001), having a severe COVID-19 condition (OR = 0.129, 95%CI 0.082-0.201; p <0.001), expectoration (OR = 1.796, 95%CI 1.062-3.036; p 0.029), muscle ache (OR = 0.309, 95%CI 0.153-0.626; p 0.001), and decreased albumin (OR = 1.929, 95%CI 1.199-3.104; p 0.007) as being associated with unimprovement in COVID-19 patients. CONCLUSION: Male sex, a severe COVID-19 condition, expectoration, muscle ache, and decreased albumin were independent risk factors which influence the improvement of COVID-19 patients.
  • |*Disease Progression[MESH]
  • |*Patient Acuity[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |China/epidemiology[MESH]
  • |Chronic Disease[MESH]
  • |Coronavirus Infections/blood/complications/*mortality/*therapy[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Myalgia/virology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/blood/complications/*mortality/*therapy[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Serum Albumin/metabolism[MESH]
  • |Sex Factors[MESH]
  • |Symptom Assessment[MESH]
  • |Treatment Failure[MESH]
  • |Young Adult[MESH]


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  • suck abstract from ncbi

    767 6.26 2020