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10.1016/j.jaut.2020.102463 http://scihub22266oqcxt.onion/10.1016/j.jaut.2020.102463 32303424!7152872!32303424     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Autoimmun 2020 ; 112 (ä): 102463 Nephropedia Template TP {{tp|p=32303424|t=2020. Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19 |pdf=|usr=}}{{32303424}} gab.com Text Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19 JO: J Autoimmun http://www.kidney.de/pget.php?&tw=1&pmid=32303424 #FOAvip It has been reported that SARS-CoV-2 may use ACE2 as a receptor to gain entry into human cells, in a way similar to that of SARS-CoV. Analyzing the distribution and expression level of ACE2 may therefore help reveal underlying mechanisms of viral susceptibility and post-infection modulation. In this study, we utilized previously uploaded information on ACE2 expression in various conditions including SARS-CoA to evaluate the role of ACE2 in SARS-CoV and extrapolate that to COVID-19. We found that the expression of ACE2 in healthy populations and patients with underlying diseases was not significantly different. However, based on the elevated expression of ACE2 in cigarette smokers, we speculate that long-term smoking may be a risk factor for COVID-19. Analysis of ACE2 in SARS-CoV infected cells suggests that ACE2 is not only a receptor but is also involved in post-infection regulation, including immune response, cytokine secretion, and viral genome replication. Moreover, we constructed Protein-protein interaction (PPI) networks and identified hub genes in viral activity and cytokine secretion. Our findings may help clinicians and researchers gain more insight into the pathogenesis of SARS-CoV-2 and design therapeutic strategies for COVID-19. Twit Text FOAVip Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19 ????J Autoimmun http://www.kidney.de/pget.php?&tw=1&pmid=32303424 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32303424 #FOAvip English Wikipedia <ref>{{Cite pmid|32303424}}</ref> Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19 #MMPMID32303424 Li G; He X; Zhang L; Ran Q; Wang J; Xiong A; Wu D; Chen F; Sun J; Chang C J Autoimmun 2020[Aug]; 112 (ä): 102463 PMID32303424show ga It has been reported that SARS-CoV-2 may use ACE2 as a receptor to gain entry into human cells, in a way similar to that of SARS-CoV. Analyzing the distribution and expression level of ACE2 may therefore help reveal underlying mechanisms of viral susceptibility and post-infection modulation. In this study, we utilized previously uploaded information on ACE2 expression in various conditions including SARS-CoA to evaluate the role of ACE2 in SARS-CoV and extrapolate that to COVID-19. We found that the expression of ACE2 in healthy populations and patients with underlying diseases was not significantly different. However, based on the elevated expression of ACE2 in cigarette smokers, we speculate that long-term smoking may be a risk factor for COVID-19. Analysis of ACE2 in SARS-CoV infected cells suggests that ACE2 is not only a receptor but is also involved in post-infection regulation, including immune response, cytokine secretion, and viral genome replication. Moreover, we constructed Protein-protein interaction (PPI) networks and identified hub genes in viral activity and cytokine secretion. Our findings may help clinicians and researchers gain more insight into the pathogenesis of SARS-CoV-2 and design therapeutic strategies for COVID-19. |*Gene Expression Regulation, Enzymologic[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/*metabolism[MESH] |COVID-19[MESH] |Coronavirus Infections/*enzymology/pathology[MESH] |Humans[MESH] |Lung/*enzymology[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*biosynthesis[MESH] |Pneumonia, Viral/*enzymology/pathology[MESH] |Protein Interaction Maps[MESH] |SARS-CoV-2[MESH]Assessing ACE2 expression patterns in lung tissues in the pathogenesis(epmc).pdf DeepDyve Pubget Overpricing