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10.1002/jmv.25898 http://scihub22266oqcxt.onion/10.1002/jmv.25898 32297988!7262144!32297988     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2020 ; 92 (7): 776-785 Nephropedia Template TP {{tp|p=32297988|t=2020. Virological and clinical cure in COVID-19 patients treated with hydroxychloroquine: A systematic review and meta-analysis |pdf=|usr=}}{{32297988}} gab.com Text Virological and clinical cure in COVID-19 patients treated with hydroxychloroquine: A systematic review and meta-analysis JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32297988 #FOAvip Following the demonstration of the efficacy of hydroxychloroquine against severe acute respiratory syndrome coronavirus 2 in vitro, many trials started to evaluate its efficacy in clinical settings. However, no systematic review and meta-analysis have addressed the issue of the safety and efficacy of hydroxychloroquine (HCQ) in coronavirus disease 2019. We conducted a systematic review and meta-analysis with the objectives of evaluation of safety and efficacy of HCQ alone or in combination in terms of "time to clinical cure," "virological cure," "death or clinical worsening of disease," "radiological progression," and safety. RevMan was used for meta-analysis. We searched 16 literature databases out of which seven studies (n = 1358) were included in the systematic review. In terms of clinical cure, two studies reported possible benefit in "time to body temperature normalization" and one study reported less "cough days" in the HCQ arm. Treatment with HCQ resulted in less number of cases showing the radiological progression of lung disease (odds ratio [OR], 0.31, 95% confidence interval [CI], 0.11-0.9). No difference was observed in virological cure (OR, 2.37, 95% CI, 0.13-44.53), death or clinical worsening of disease (OR, 1.37, 95% CI, 1.37-21.97), and safety (OR, 2.19, 95% CI, 0.59-8.18), when compared with the control/conventional treatment. Five studies reported either the safety or efficacy of HCQ + azithromycin. Although seems safe and effective, more data are required for a definitive conclusion. HCQ seems to be promising in terms of less number of cases with radiological progression with a comparable safety profile to control/conventional treatment. We need more data to come to a definite conclusion. Twit Text FOAVip Virological and clinical cure in COVID-19 patients treated with hydroxychloroquine: A systematic review and meta-analysis ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32297988 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32297988 #FOAvip English Wikipedia <ref>{{Cite pmid|32297988}}</ref> Virological and clinical cure in COVID-19 patients treated with hydroxychloroquine: A systematic review and meta-analysis #MMPMID32297988 Sarma P; Kaur H; Kumar H; Mahendru D; Avti P; Bhattacharyya A; Prajapat M; Shekhar N; Kumar S; Singh R; Singh A; Dhibar DP; Prakash A; Medhi B J Med Virol 2020[Jul]; 92 (7): 776-785 PMID32297988show ga Following the demonstration of the efficacy of hydroxychloroquine against severe acute respiratory syndrome coronavirus 2 in vitro, many trials started to evaluate its efficacy in clinical settings. However, no systematic review and meta-analysis have addressed the issue of the safety and efficacy of hydroxychloroquine (HCQ) in coronavirus disease 2019. We conducted a systematic review and meta-analysis with the objectives of evaluation of safety and efficacy of HCQ alone or in combination in terms of "time to clinical cure," "virological cure," "death or clinical worsening of disease," "radiological progression," and safety. RevMan was used for meta-analysis. We searched 16 literature databases out of which seven studies (n = 1358) were included in the systematic review. In terms of clinical cure, two studies reported possible benefit in "time to body temperature normalization" and one study reported less "cough days" in the HCQ arm. Treatment with HCQ resulted in less number of cases showing the radiological progression of lung disease (odds ratio [OR], 0.31, 95% confidence interval [CI], 0.11-0.9). No difference was observed in virological cure (OR, 2.37, 95% CI, 0.13-44.53), death or clinical worsening of disease (OR, 1.37, 95% CI, 1.37-21.97), and safety (OR, 2.19, 95% CI, 0.59-8.18), when compared with the control/conventional treatment. Five studies reported either the safety or efficacy of HCQ + azithromycin. Although seems safe and effective, more data are required for a definitive conclusion. HCQ seems to be promising in terms of less number of cases with radiological progression with a comparable safety profile to control/conventional treatment. We need more data to come to a definite conclusion. |*Pandemics[MESH] |Antiviral Agents/*therapeutic use[MESH] |Azithromycin/therapeutic use[MESH] |Betacoronavirus/drug effects/growth & development/pathogenicity[MESH] |COVID-19[MESH] |Clinical Trials as Topic[MESH] |Coronavirus Infections/complications/*drug therapy/*epidemiology/metabolism[MESH] |Drug Therapy, Combination/methods[MESH] |Humans[MESH] |Hydroxychloroquine/*therapeutic use[MESH] |Pneumonia, Viral/complications/*drug therapy/*epidemiology/metabolism[MESH] |SARS-CoV-2[MESH] |Treatment Outcome[MESH] |Viral Load/drug effects[MESH]Virological and clinical cure in COVID-19 patients treated with hydro(epmc).pdf DeepDyve Pubget Overpricing