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10.2174/0929867327666200416131117

http://scihub22266oqcxt.onion/10.2174/0929867327666200416131117
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32297571!ä!32297571

suck abstract from ncbi


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pmid32297571      Curr+Med+Chem 2020 ; 27 (27): 4536-4541
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  • SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and other Drugs for the Treatment of the New Coronavirus #MMPMID32297571
  • Costanzo M; De Giglio MAR; Roviello GN
  • Curr Med Chem 2020[]; 27 (27): 4536-4541 PMID32297571show ga
  • Here we report on the most recent updates on experimental drugs successfully employed in the treatment of the disease caused by SARS-CoV-2 coronavirus, also referred to as COVID-19 (COronaVIrus Disease-19). In particular, several cases of recovered patients have been reported after being treated with lopinavir/ritonavir [which is widely used to treat Human Immunodeficiency Virus (HIV) infection] in combination with the anti-flu drug oseltamivir. In addition, remdesivir, which has been previously administered to Ebola virus patients, has also proven effective in the U.S. against coronavirus, while antimalarial chloroquine and hydroxychloroquine, favipiravir and co-administered darunavir and umifenovir (in patient therapies) were also recently recorded as having anti-SARS-CoV-2 effects. Since the recoveries/deaths ratio in the last weeks significantly increased, especially in China, it is clear that the experimental antiviral therapy, together with the availability of intensive care unit beds in hospitals and rigorous government control measures, all play an important role in dealing with this virus. This also stresses the urgent need for the scientific community to devote its efforts to the development of other more specific antiviral strategies.
  • |Adenosine Monophosphate/analogs & derivatives[MESH]
  • |Alanine/analogs & derivatives[MESH]
  • |Amides[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |China[MESH]
  • |Coronavirus Infections/*drug therapy[MESH]
  • |Darunavir[MESH]
  • |Drug Combinations[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine[MESH]
  • |Indoles[MESH]
  • |Lopinavir[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy[MESH]
  • |Pyrazines[MESH]
  • |Ritonavir[MESH]


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