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10.1093/cid/ciaa444

http://scihub22266oqcxt.onion/10.1093/cid/ciaa444
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32296817!7184504!32296817
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suck abstract from ncbi


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pmid32296817      Clin+Infect+Dis 2020 ; 71 (15): 879-881
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  • Importance of Inclusion of Pregnant and Breastfeeding Women in COVID-19 Therapeutic Trials #MMPMID32296817
  • LaCourse S; John-Stewart G; Adams Waldorf KM
  • Clin Infect Dis 2020[Jul]; 71 (15): 879-881 PMID32296817show ga
  • Investigators are employing unprecedented innovation in the design of clinical trials to rapidly and rigorously assess potentially promising therapies for coronavirus disease 2019 (COVID-19); this is in stark contrast to the continued near-universal regressive practice of exclusion of pregnant and breastfeeding women from these trials. The few trials that allow their inclusion focus on postexposure prophylaxis or outpatient treatment of milder disease, limiting the options available to pregnant women with severe COVID-19 to compassionate use of remdesivir, or off-label drug use of hydroxychloroquine or other therapies. These restrictions were put in place despite experience with these drugs in pregnant women. In this Viewpoint, we call attention to the need and urgency to engage pregnant women in COVID-19 treatment trials now in order to develop data-driven recommendations regarding the risks and benefits of therapies in this unique but not uncommon population.
  • |Antiviral Agents/therapeutic use[MESH]
  • |Betacoronavirus/*drug effects[MESH]
  • |Breast Feeding[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/*drug therapy/virology[MESH]
  • |Drug Administration Schedule[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/therapeutic use[MESH]
  • |Off-Label Use[MESH]
  • |Outpatients[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/virology[MESH]
  • |Post-Exposure Prophylaxis/methods[MESH]
  • |Pregnancy[MESH]
  • |Pregnancy Complications, Infectious/drug therapy/virology[MESH]
  • |SARS-CoV-2[MESH]


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