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10.1016/j.virusres.2020.197976

http://scihub22266oqcxt.onion/10.1016/j.virusres.2020.197976
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suck abstract from ncbi


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pmid32294518      Virus+Res 2020 ; 283 (ä): 197976
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  • A comprehensive analysis of genome composition and codon usage patterns of emerging coronaviruses #MMPMID32294518
  • Tort FL; Castells M; Cristina J
  • Virus Res 2020[Jul]; 283 (ä): 197976 PMID32294518show ga
  • An outbreak of atypical pneumonia caused by a novel Betacoronavirus (betaCoV), named SARS-CoV-2 has been declared a public health emergency of international concern by the World Health Organization. In order to gain insight into the emergence, evolution and adaptation of SARS-CoV-2 viruses, a comprehensive analysis of genome composition and codon usage of betaCoV circulating in China was performed. A biased nucleotide composition was found for SARS-CoV-2 genome. This bias in genomic composition is reflected in its codon and amino acid usage patterns. The overall codon usage in SARS-CoV-2 is similar among themselves and slightly biased. Most of the highly frequent codons are A- and U-ending, which strongly suggests that mutational bias is the main force shaping codon usage in this virus. Significant differences in relative synonymous codon usage frequencies among SARS-CoV-2 and human cells were found. These differences are due to codon usage preferences.
  • |*Genomics[MESH]
  • |Amino Acids/genetics[MESH]
  • |Animals[MESH]
  • |Betacoronavirus/*classification/*genetics/isolation & purification[MESH]
  • |China/epidemiology[MESH]
  • |Chiroptera/virology[MESH]
  • |Codon Usage/*genetics[MESH]
  • |Communicable Diseases, Emerging/*virology[MESH]
  • |Coronavirus Infections/epidemiology/veterinary/virology[MESH]
  • |Evolution, Molecular[MESH]
  • |Ferrets/virology[MESH]
  • |Gene Expression Regulation, Viral/*genetics[MESH]
  • |Genome, Viral/*genetics[MESH]
  • |Humans[MESH]
  • |Mutagenesis/genetics[MESH]
  • |Open Reading Frames/genetics[MESH]
  • |SARS-CoV-2[MESH]


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