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10.1002/jmv.25884

http://scihub22266oqcxt.onion/10.1002/jmv.25884
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32293716!7262119!32293716
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suck abstract from ncbi


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pmid32293716      J+Med+Virol 2020 ; 92 (10): 1902-1914
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  • Clinical characteristics of 3062 COVID-19 patients: A meta-analysis #MMPMID32293716
  • Zhu J; Ji P; Pang J; Zhong Z; Li H; He C; Zhang J; Zhao C
  • J Med Virol 2020[Oct]; 92 (10): 1902-1914 PMID32293716show ga
  • We aimed to systematically review the clinical characteristics of coronavirus disease 2019 (COVID-19). Seven databases were searched to collect studies about the clinical characteristics of COVID-19 from January 1, 2020 to February 28, 2020. Then, meta-analysis was performed by using Stata12.0 software. A total of 38 studies involving 3062 COVID-19 patients were included. Meta-analysis showed that a higher proportion of infected patients was male (56.9%). The incidence rate of respiratory failure or acute respiratory distress syndrome was 19.5% and the fatality rate was 5.5%. Fever (80.4%), fatigue (46%), cough (63.1%), and expectoration (41.8%) were the most common clinical manifestations. Other common symptoms included muscle soreness (33%), anorexia (38.8%), chest tightness (35.7%), shortness of breath (35%), dyspnea (33.9%). Minor symptoms included nausea and vomiting (10.2%), diarrhea (12.9%), headache (15.4%), pharyngalgia (13.1%), shivering (10.9%), and abdominal pain (4.4%). The proportion of patients that was asymptomatic was 11.9%. Normal leukocyte counts (69.7%), lymphopenia (56.5%), elevated C-reactive protein levels (73.6%), elevated ESR (65.6%), and oxygenation index decreased (63.6%) were observed in most patients. About 37.2% of patients were found with elevated D-dimer, 25.9% of patients with leukopenia, along with abnormal levels of liver function (29%), and renal function (25.5%). Other findings included leukocytosis (12.6%) and elevated procalcitonin (17.5%). Only 25.8% of patients had lesions involving a single lung and 75.7% of patients had lesions involving bilateral lungs. The most commonly experienced symptoms of COVID-19 patients were fever, fatigue, cough, and expectoration. A relatively small percentage of patients were asymptomatic. Most patients showed normal leucocytes counts, lymphopenia, elevated levels of C-reactive protein and ESR. Bilateral lung involvement was common.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |C-Reactive Protein/metabolism[MESH]
  • |COVID-19/*diagnosis/metabolism/virology[MESH]
  • |Child[MESH]
  • |Cough/diagnosis/metabolism/virology[MESH]
  • |Diarrhea/diagnosis/metabolism/virology[MESH]
  • |Fatigue/diagnosis/metabolism/virology[MESH]
  • |Female[MESH]
  • |Fever/diagnosis/metabolism/virology[MESH]
  • |Humans[MESH]
  • |Lung/metabolism/virology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnosis/metabolism/virology[MESH]
  • |Respiratory Insufficiency/diagnosis/metabolism/virology[MESH]
  • |SARS-CoV-2/pathogenicity[MESH]


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