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  • Prognostic value of NT-proBNP in patients with severe COVID-19 #MMPMID32293449
  • Gao L; Jiang D; Wen XS; Cheng XC; Sun M; He B; You LN; Lei P; Tan XW; Qin S; Cai GQ; Zhang DY
  • Respir Res 2020[Apr]; 21 (1): 83 PMID32293449show ga
  • BACKGROUND: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The cardiac injury is a common condition among the hospitalized patients with COVID-19. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome of severe COVID-19 patients was unknown. METHODS: The study initially enrolled 102 patients with severe COVID-19 from a continuous sample. After screening out the ineligible cases, 54 patients were analyzed in this study. The primary outcome was in-hospital death defined as the case fatality rate. Research information and following-up data were obtained from their medical records. RESULTS: The best cut-off value of NT-proBNP for predicting in-hospital death was 88.64 pg/mL with the sensitivity for 100% and the specificity for 66.67%. Patients with high NT-proBNP values (> 88.64 pg/mL) had a significantly increased risk of death during the days of following-up compared with those with low values (
  • |*Coronavirus Infections/diagnosis/mortality[MESH]
  • |*Hospital Mortality[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/diagnosis/mortality[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Betacoronavirus[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Mortality[MESH]
  • |Natriuretic Peptide, Brain/*analysis[MESH]
  • |Peptide Fragments/*analysis[MESH]
  • |Predictive Value of Tests[MESH]
  • |Prognosis[MESH]
  • |Reference Values[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]

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  • suck abstract from ncbi

    83 1.21 2020