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10.1016/j.jaut.2020.102452

http://scihub22266oqcxt.onion/10.1016/j.jaut.2020.102452
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32291137!7151347!32291137
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suck abstract from ncbi


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pmid32291137      J+Autoimmun 2020 ; 111 (ä): 102452
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  • Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)? #MMPMID32291137
  • Liu B; Li M; Zhou Z; Guan X; Xiang Y
  • J Autoimmun 2020[Jul]; 111 (ä): 102452 PMID32291137show ga
  • The emergent outbreak of coronavirus disease 2019 (COVID-19) has caused a global pandemic. Acute respiratory distress syndrome (ARDS) and multiorgan dysfunction are among the leading causes of death in critically ill patients with COVID-19. The elevated inflammatory cytokines suggest that a cytokine storm, also known as cytokine release syndrome (CRS), may play a major role in the pathology of COVID-19. However, the efficacy of corticosteroids, commonly utilized antiinflammatory agents, to treat COVID-19-induced CRS is controversial. There is an urgent need for novel therapies to treat COVID-19-induced CRS. Here, we discuss the pathogenesis of severe acute respiratory syndrome (SARS)-induced CRS, compare the CRS in COVID-19 with that in SARS and Middle East respiratory syndrome (MERS), and summarize the existing therapies for CRS. We propose to utilize interleukin-6 (IL-6) blockade to manage COVID-19-induced CRS and discuss several factors that should be taken into consideration for its clinical application.
  • |Anti-Inflammatory Agents/therapeutic use[MESH]
  • |Antibodies, Monoclonal, Humanized/*therapeutic use[MESH]
  • |Betacoronavirus/pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*pathology[MESH]
  • |Cytokine Release Syndrome/*therapy[MESH]
  • |Humans[MESH]
  • |Immunomodulation/drug effects[MESH]
  • |Interleukin-6/*antagonists & inhibitors/blood[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*pathology[MESH]
  • |SARS-CoV-2[MESH]


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